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Lung India Official publication of Indian Chest Society  
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Year : 1983  |  Volume : 1  |  Issue : 3  |  Page : 106-110

Experiences With A Mucolytic Aerosol Preparation (MESNA) In Patients With Chronic Lung Diseases



Correspondence Address:
S. R Kamat


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Source of Support: None, Conflict of Interest: None


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An open study of sodium 2 mercapto ethane-sulphonate (MESNA) daily over 10 days was done in 30 subjects with chronic lung diseases and sputum production. While 13 of them showed improvement, five deteriorated clinically. There was a reduction in sputum quantity in 11 subjects; sputum viscosity improved in all over two hours and in 26 subjects progressively. Moderately severe side effects were seen in six of 24 subjects in whom complaints like burning chest pain, increased dyspnoea, vomiting, headache, and giddiness were observed. There was significant decrease in FEV1 and FVC (but not PEF) which was maximal at 20-40 minutes and reversed later. MESNA aerosol merits further evaluation as a mucolytic in subjects with serious disease.


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