Source of Support: None, Conflict of Interest: None
A policy trial was conducted to determine to what extent the intermittent short Course chemotherapy was effective in regard to efficacy of treatment; particularly with intermittent regimens containing Streptomycin (S), lsoniazid (H), Rifampicin (R) and Pyrazinamide (Z). Ninety-five bacteriologically proved pulmonary tuberculosis patients were drawn for the study. There remained 89 patients for the main analysis after exclusion of six patients. The treatment regimen was SHRZ on alternate days for two months followed by twice-weekly SHRZ for another five months. Default rate was minimal. Regularity in drug collection during these seven months treatment was quite satisfactory in this easily accessible closed population. Bacteriological assessment revealed 100% bacteriological conversion in freshly diagnosed patients Radiological assessment with regard to clearance of lesion and cavity closure were also studied; 53% of patients showing complete or two third clearance. Adverse reaction to drugs were very infrequent. Follow up of 55 patients revealed encouraging results. Thus, at the end of 17 months only four of 55 patients showed relapse with positive smear results.