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Lung India Official publication of Indian Chest Society  
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Year : 1984  |  Volume : 2  |  Issue : 1  |  Page : 143-145

Assay Of Ethambutol In Pharmaceutical Preparations



Correspondence Address:
Prema Gurumurthy


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Source of Support: None, Conflict of Interest: None


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Ethambutol tablets of 200 and 300 mg denominations were assayed by the standard non-aqueous titration method and a simpler colorimetric method. With the titrimetric method, assay values, appreciably higher than the stated content (117% or more), were obtained with the products of 4 companies, while all the values were within 6% of the stated content by the colorimetric method. Rifampicin and pyrazinamide interfered with the estimation of ethambutol by both methods; isoniazid, however, caused an overestimation with the titrimetric method only.


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