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Prealbumin, a normal component of human serum is reported to be rich in the amino acid tryptophan. Its normal concentration is 28 to 35 mg per 100 ml. It is decreased in blood and biofluids in tuberculous conditions. Blood-serum in pulmonary tuberculosis, cerebrospinal fluid (C.S.F) in tuberculous meningitis, pleural fluid in tuberculous effusion and ascitic fluid in tuberculous peritonitis did not show prealbumin, when examined by polyacrylsmide gel disc electrophoresis. Tryptophan is reported to accumulate in C.S.F. in tuberculous meningitis. In pulmonary tuberculosis, once treatment was restored to, no decrease of prealbumin levels in blood-serum, was observed.