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Lung India Official publication of Indian Chest Society  
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Year : 1991  |  Volume : 9  |  Issue : 2  |  Page : 52-56

Effective Short Course Chemotherapy For Pulmonary Tuberculosis Under Field Conditions



Correspondence Address:
S Rajasekaran


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Source of Support: None, Conflict of Interest: None


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A short-course chemotherapy trial was undertaken to evaluate the efficacy and the reliability of a self-administered Intermittent drug scheme in the existing programme conditions, after in initial period of one month hospitalisation. 1184 newly diagnosed and bacteriologically confirmed pulmonary tuberculosis patients were treated for six months with 1 S7 R7 H7 Z7 + 5H2 R2 drug regimen. The continuation phase of Intermittent chemotherapy was totally unsupervised. Treatment was discontinued in 39 patients due to drug toxicity. While 14 patients died during treatment, 16 others continued their treatment elsewhere. 78% patients completed treatment as per the protocol. Bacteriological conversion was 85% at the end of the two months treatment. The relapse rate was 4.9% after 30 months follow up. Thus, this self-administered intermittent short course chemotherapy is highly effective in field condition, quite acceptable to patients and economically feasible for introduction in the National Tuberculosis Control Programme.


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