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Lung India Official publication of Indian Chest Society  
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Year : 1991  |  Volume : 9  |  Issue : 3  |  Page : 90-94

Clinical And Spirometric Improvement In Bronchiectasis - Effects Of Varying Doses Of Amoxycillin

Correspondence Address:
N. K Jain

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Thirty-eight patients of bronchiectasis (20 males and 18 females) were studied to evaluate the extent of lung damage in them and to establish the dosage of amoxycillin required to achieve clearance of secretions with clinical response. The improvement in VC, FEV1, PEFR and FEF 25-75% was statistically highly significant after one week amoxycillin administration and after two weeks therapy the improvement remained highly significant in FEV1 and character or amount of expectoration. 250 mg of amoxycillin three times a day (Regimen I) was found to be effective in only 33.3% cases with mucoid expectoration. 500 mg of amoxycillin three times a day (Regimen II) in 79% cases with mucopurulent expectoration and 1.5 gm amoxycillin twice a day (Regimen III) in 25% cases with persistently purulent expectoration. Three grams amoxycillin twice a day was found to be effective in 66.6% failures of Regimen II. 500 mg amoxcillin three times a day is suggested as an effective, logical and economical choice for patients with mucoid and mucopurulent expectoration. Patients with persistently purulent secretions require vigorous antibiotic course on individual basis based on result of culture and sensitivity studies.

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