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Lung India Official publication of Indian Chest Society  
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Year : 1991  |  Volume : 9  |  Issue : 3  |  Page : 95-98

Rifampicin-Metoclopramide Interaction - A Clinico Pharmacological Study



Correspondence Address:
S. D Purohit


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Untreated patients of pulmonary tuberculosis were given a rifampicin containing drug regimen along with placebo (Group I) or metoclopramide (Group II). Gastric emptying time, gastric pH, serum level of rifampicin and urinary excretion of rifampicin were estimated at different time intervals in all the patients. Adverse reactions, if any, were recorded. Metoclopramide led to a significant decline in gastric emptying time and rise in gastric pH. Mean peak serum levels of rifampicin were achieved earlier (90 minutes v/s 120 minutes) and were higher (9.82 ± 1.8 mg/ml v/s 8.14 ± 2.5 mg/ml) in presence of metoclopramide as compared to placebo. Metoclopramide did not change the frequency of rifampicin induced hepatitis but epigastric pain was significantly less.


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