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Lung India Official publication of Indian Chest Society  
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Year : 1992  |  Volume : 10  |  Issue : 2  |  Page : 51-55

Negative Effects Of Salbutamol On Pharmacokinetics And Clinical Efficacy Of Theophylline



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S. D Purohit


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Mean theophylline levels were 14.85 ± 2.75 mcg/ml and 12.05 ± 1.12 mcg/ml, when the patients received theophylline alone intravenously and orally respectively. When salbutamol was added the respective theophylline levels were 12.13 ± 3.37 mcg/ml and 10.51 ± 1.76 mcg/ml only. The differences were statistically significant (p < 0.05). Post therapy pulmonary functions were significantly higher after intravenous theophylline alone as compared to theophylline intravenously along with oral salbutamol. Although the post therapy pulmonary functions were higher in patients with oral theophylline plus salbutamol as compared to oral theophylline alone, the spirometric indices were smaller when compared to oral salbutamol alone. Similar observations were noted subjectively. Adverse effects in the form of palpitation, tremors, nausea, tachycardia and fall in diastolic blood pressure were significantly more with combined therapy as compared to either drug alone.


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