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Lung India Official publication of Indian Chest Society  
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Year : 1993  |  Volume : 11  |  Issue : 3  |  Page : 103-106

Effect Of Pentoxifylline On Lung Function, Respiratory Muscle Pressures And Bronchial Responsiveness In Asthma



Correspondence Address:
D Talwar


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Source of Support: None, Conflict of Interest: None


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Effect of pentoxifylline, a new dimethyl xanthine, was studied, on respiratory functions and methacholine induced bronchoconstriction in nine stable asthmatics, in a placebo controlled trial. The average PC20 ratio of 2.32±1.26, signifying more than two-fold protection, showed that pentoxifylline inhibited cholinergic induced bronchoconstriction. Maximum inspiratory and expiratory pressures also showed significant improvement (35.8±29.6% and 19.7±7.5% respectively), but the expiratory flows did not change. Transient and reversible fall in blood pressure and rise in heart rate were noticed during pentoxifylline infusion.


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