Source of Support: None, Conflict of Interest: None
The diffusing capacity for carbon monoxide (DLCO) In healthy subjects before and after ingestion of 100 ml of 75% proof, 42.8% v/v whisky to determine if alcohol could acutely change DLCO. The effects of acute alcohol ingestion on the forced expiratory flow rates and peak flow rate before and after alcohol were also studied. An insignificant decrease was found in DLCO thirty minutes after ingestion of alcohol (p>0.05), but significant decreases were found 60, 90 and 120 minutes after alcohol (p<0.001), the maximum decrease being at 90 minutes. The effects of acute alcohol ingestion on the forced expiratory flow rates were inconsistent. The possible causes leading to the decrease are discussed.