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Lung India Official publication of Indian Chest Society  
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Year : 1993  |  Volume : 11  |  Issue : 4  |  Page : 139-141

Estimation Of Adenosine Deaminase, Alpha 1 - Anti Trypsin And Protease Inhibitors In Pleural Effusions



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K. M Remeshchandra Babu


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Adenosine Deaminase (ADA) activity, alpha 1 – anti trypsin and protease inhibitors were estimated in a total of 20 cases of pleural effusion, of which 11 were tuberculous, seven mallgnant and two cases of pyothorax. Fitteeen age and sex matched normal adults formed the control group. The ADA activity (mean ± SD U/L) in control sera was 4.6 ± 1.4 U/L. ADA was significantly elevated in tuberculous effusion (37.8 ± 9.6) compared to malignant effustion (17.7 ± 6.2) or pyothorax (17.7 ± 5.4) (p < 0.001). The alpha 1 – anti trypsin (AAT) (mg %) in control sera was 237.2 ± 39.8. Alpha 1 – antitrypsin was found elevated in tuberculous effusion (327.4 ± 46.3) but not in malignant effusion (260.7 ± 94.5) or pyothorax (207.5 ± 11.5) (p < 0.001). Estimation of protease inhibitory activity is not useful in differentiating tuberculous effusion from malignant effusion or pyothorax.


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