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Lung India Official publication of Indian Chest Society  
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Year : 1995  |  Volume : 13  |  Issue : 2  |  Page : 56-59

Drug Resistance Pattern Of Mycobacterium Tuberculosis In A Chest Diseases Hospital Of Armed Forces



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J Jena


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Drug susceptibility testing was carried out on all isolates of M. Tubercilosis, Sixty patients grow Mycobacterium Tuberculosis with in vitro resistance to various drugs out to 473 positive cultures (12.7%). Single drug resistance was commonest and observed in 38 out of 60 (63.3%) strains, double drug resistance in 15 (25%) and resistance to three or more drugs in seven (11.7%). Of 18 cases of relapse after short course chemotherapy, seven had drug resistant strains. All of these showed resistance of rifampicin. There was a small group of patients (ten) consisting of family members of soldiers, who showed drug resistant strains, of which six showed multidrug resistance. There were six resistant cases amongst a total of 33 patients of Tibetan origin, whereas there were three resistant cases amongst a total of 40 patients of Nepali origin. There was no significant statistical difference in occurrence of resistance amongst patients of Tibetan and Nepali origin when compared with each other (p>0.05). However, a significant difference in the occurrence of resistance amongst patients of Nepali/Tibetan origin and patients of Indian origin was found (p<0.05), with the incidence of resistance being higher in the former groups.


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