Home | About us | Editorial Board | Search | Ahead of print | Current Issue | Archives | Instructions | Online submissionContact Us   |  Subscribe   |  Advertise   |  Login  Page layout
Wide layoutNarrow layoutFull screen layout
Lung India Official publication of Indian Chest Society  
  Users Online: 1334   Home Print this page  Email this page Small font size Default font size Increase font size
Year : 1996  |  Volume : 14  |  Issue : 3  |  Page : 121-124

Estimation Of T4/T8 Ratio In Patients With Sarcoidosis, Diffuse Interstitial Pulmonary Fibrosis And Pulmonary Tuberculosis



Correspondence Address:
V Mahbubani


Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

The total T lymphocyte population (T11 counts) and relative proportions of helper T cells (T4) and suppressor T cells (T8) were determined in the peripheral blood and bronhoalveolar lavage fluid of sarcoidosis, diffuse interstitial pulmonary fibrosis and pulmonary patients to assess the state of systemic and local cell mediated immunocompetence. In peripheral blood, T4/T8 ratio in sarcoidosis (1.37 ± 0.17 vs 2.1 ± 0.35, p<0.01) and total T lymphocytes in pulmonary tuberculosis (51.2 ± 7.5 vs 64.8 ± 9.1, p<0.01) were significantly lower compared to control subjects. There was no difference in either T4/T8 ratio or total T cells in diffuse interstitial pulmonary fibrosis. The mean T4/T8 ratio in bronchoalveolar lavage fluid was 1.7 ± 0.4 in sarcoidosis, 1.4 ± 0.1 in diffuse interstitial pulmonary fibrosis and 1.9 ± 0.6 in pulmonary tuberculosis. The results indicate significant alterations in T cell subset dynamics that seem to contribute to the pathogenesis of sarcoidosis and pulmonary tuberculosis.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed480    
    Printed25    
    Emailed0    
    PDF Downloaded81    
    Comments [Add]    

Recommend this journal