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Lung India Official publication of Indian Chest Society  
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Year : 1996  |  Volume : 14  |  Issue : 3  |  Page : 121-124

Estimation Of T4/T8 Ratio In Patients With Sarcoidosis, Diffuse Interstitial Pulmonary Fibrosis And Pulmonary Tuberculosis

Correspondence Address:
V Mahbubani

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Source of Support: None, Conflict of Interest: None

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The total T lymphocyte population (T11 counts) and relative proportions of helper T cells (T4) and suppressor T cells (T8) were determined in the peripheral blood and bronhoalveolar lavage fluid of sarcoidosis, diffuse interstitial pulmonary fibrosis and pulmonary patients to assess the state of systemic and local cell mediated immunocompetence. In peripheral blood, T4/T8 ratio in sarcoidosis (1.37 ± 0.17 vs 2.1 ± 0.35, p<0.01) and total T lymphocytes in pulmonary tuberculosis (51.2 ± 7.5 vs 64.8 ± 9.1, p<0.01) were significantly lower compared to control subjects. There was no difference in either T4/T8 ratio or total T cells in diffuse interstitial pulmonary fibrosis. The mean T4/T8 ratio in bronchoalveolar lavage fluid was 1.7 ± 0.4 in sarcoidosis, 1.4 ± 0.1 in diffuse interstitial pulmonary fibrosis and 1.9 ± 0.6 in pulmonary tuberculosis. The results indicate significant alterations in T cell subset dynamics that seem to contribute to the pathogenesis of sarcoidosis and pulmonary tuberculosis.

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