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Lung India Official publication of Indian Chest Society  
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Year : 1999  |  Volume : 17  |  Issue : 1  |  Page : 15-18

Combination Therapy With Salbutamol And Ipratropium Bromide In Stable Patients Of Chronic Obstructive Pulmonary Disease



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R Bhargava


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This study was conducted to compare the efficacy of salbutamol alone and ipratropium bromide alone with salbutamol plus ipratropium bromide combined, through inhalational route in stable patients of chronic obstructive pulmonary disease (COPD). The study was carried out in 97 patients of COPD. Salbutamol inhalation was administered to 32 patients and ipratropium bromide inhalation was given to 29 patients. 36 patients were treated with the combination of salbutamol and ipratropium bromide inhalations. Pulmonary functions were recorded before and after 15, 30, 60, 120, 180 and 240 minutes of inhalation of bronchodilator drug(s). Bronchodilation was significantly more in patients treated with the combination therapy as compared to patients treated with salbutamol or ipratropium bromide separately. It was more sustained in the combination therapy, as the effect started declining after 120 minites in salbutamol, after 180 minutes in ipratropium bromide and after 240 minutes in combination therapy with ipratropium and salbutamol. Thus, ipratropium bromide plus salbutamol combination therapy is better in patients of COPD than treated with either of the agents alone.


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