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Lung India Official publication of Indian Chest Society  
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Year : 2001  |  Volume : 19  |  Issue : 4  |  Page : 97-100

A Placebo Controlled Evaluation Of Intravenous Aminophylline In Acute Asthma



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J Whig


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In a placebo-controlled study; forty patients of acute asthma were randomly allocated to two groups of 20 patients each. The treatment group received Aminophylline bolus injection followed by infusion, in addition to intravenous hydrocortisone and nebulised salbutamol. The control group received placebo instead of aminophylline. Rest of the treatment remained the same. Both the groups were followed up for 13 hours during which their clinical response in the form of Wood's asthma score and objective response by Peak Expiratory Flow Rate (PEFR) was monitored at 0,1,5,9 and 13 hours. Aminophylline levels were estimated at 2 and 8 hours. Wood’s asthma score and PEFR showed significant improvement in both the groups as compared to 0 hour (p<0.001) but the two groups did not differ from each other at any point of time (p<0.05). The mean serum theophylline concentration in the treatment group was 14.93±4.33 µg/dl at 2 hours and 14.64±4.7 µg/dl at 8 hours, both of which were within the therapeutic range. The adverse drug reactions were more frequent in the treatment group as compared to the control group. Our study showed that theophylline adds to the toxicity and cost of treatment of acute asthma with no additional benefit.


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