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Lung India Official publication of Indian Chest Society  
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Year : 2007  |  Volume : 24  |  Issue : 2  |  Page : 54-57

Multidrug resistant tuberculosis: Role of previous treatment with second line therapy on treatment outcome

Department of Respiratory Medicine, B.Y. L. Nair Ch Hospital, Mumbai-8., India

Correspondence Address:
J M Joshi
Department of Respiratory Medicine, B.Y. L. Nair Ch Hospital & TN Medical College, Mumbai-8.
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0970-2113.44211

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Setting: The tuberculosis referral center of a tertiary care hospital. Objective: To determine human immunodeficiency virus (HIV) seropositivity, diabetes mellitus (DM), treatment outcome, cost, and adverse drug reaction in patients with multi­drug resistance (MDR) pulmonary tuberculosis. Design: 56 cases of MDR tuberculo­sis from April 2001 to April 2003 were included. Fasting blood sugar and three-step rapid immunoassay test for HIV was performed in all cases. 45/56 patients were able to arrange for second line drugs with the help of Medical Social Worker. Results: 1/56(1.8%) and 7/56 (12.5 %) cases were positive for HIV and DM respec­tively. Of the 45 cases started on second line drugs, 5 (11.1%) defaulted, 9 (20%) patients died, 31 patients (68.8%) completed treatment of which 19 (61%) were cured and 9 (39%) failed therapy. 17/19 (89%) who were cured had never received any second line drug previously (P=0.004 i.e. less than 0.5). The cost of therapy was $1000-2000. Adverse drug effects were seen in 13/45 patients (28.8%). Con­clusions: Successful outcome of therapy was associated with absence of previous treatment with one or more second line drugs. Treatment with second line drugs was expensive and toxic

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