|Year : 2010 | Volume
| Issue : 1 | Page : 19-23
Concomittant pulmonary tuberculosis and borderline leprosy with type-II lepra reaction in single patient
Rajendra Prasad, Sanjay Kumar Verma, Rajni Singh, Giridhar Hosmane
Department of Pulmonary Medicine, C.S.M. Medical University (erstwhile King George, Medical University), UP, Lucknow - 226 003, and G.S.V.M. Medical College, Kanpur, India
|Date of Web Publication||20-Jan-2010|
Department of Pulmonary Medicine, C.S.M. Medical University (Erstwhile King George, Medical University), UP, Lucknow - 226 003
Source of Support: None, Conflict of Interest: None
| Abstract|| |
The concommitant occurrence of both tuberculosis and leprosy in a single individual are not an uncommon clinical condition but is being reported infrequently in literature. We report a case of leprosy, diagnosed previously and also diagnosed as pulmonary tuberculosis.
Keywords: Leprosy, tuberculosis, coinfection
|How to cite this article:|
Prasad R, Verma SK, Singh R, Hosmane G. Concomittant pulmonary tuberculosis and borderline leprosy with type-II lepra reaction in single patient. Lung India 2010;27:19-23
|How to cite this URL:|
Prasad R, Verma SK, Singh R, Hosmane G. Concomittant pulmonary tuberculosis and borderline leprosy with type-II lepra reaction in single patient. Lung India [serial online] 2010 [cited 2020 Jan 21];27:19-23. Available from: http://www.lungindia.com/text.asp?2010/27/1/19/59263
| Introduction|| |
Leprosy is a chronic granulomatous disease principally affecting the skin and peripheral nervous system, caused by Mycobacterium leprae. It was discovered first time by Armauer Hansen in Norway in 1873. The infrequent occurrence of both tuberculosis and leprosy is based on the transmission dynamics of both infections. , The higher reproductive rate of Tubercle bacilli as compared to Lepra bacilli and degree of cross immunity within an individual do not allow both infections to occur simultaneously but there have been sporadic reports of co-existence of tuberculosis and leprosy in the same patients. Kumar B et al. reported that tuberculosis may occur through the spectrum of leprosy. We report a case of borderline lepromatous leprosy associated with type-II reaction and pulmonary tuberculosis in single individual.
| Case Report|| |
A 34-year-old, non- smoker male was admitted, in September 2007, to the Department of Pulmonary Medicine, as a follow through case of border line lepromatous leprosy. He had complaints of breathlessness, loss of appetite with cough with expectoration for last two and half months and skin lesions over face, forearm and dorsum of hands with exfoliative skin lesions over fore arm for last two months and recurrent haemoptysis for last 25 days. He was on medication, tab. Dapsone 100 mg daily, tab. Clofazimine 500 mg daily and cap, Rifampicin 600 mg, once a month, for the last nine months. He had also taken oral Prednisolone for more than three months duration about six months back, for neurological complications. There was no past history of tuberculosis as per information provided by the patient. Clinical examination revealed multiple hypo pigmented skin lesions varying in size from 2 to 4 cms over the trunk with thickened left ulnar nerve and nodular lesions over face, forearm and dorsum of hands [Figure 1]a and b and exfoliative skin lesions over fore arm [Figure 1]c. His resting pulse rate was 102/min and blood pressure was 112/74 mmHg and his respiratory rate was 26/min. His general examination revealed no significant abnormality. His respiratory system examination revealed coarse crepts localized to left infraclavicular and axillary areas. Initially he was put on symptomatic treatment for hemoptysis. Subsequently, his chest X-ray showed a large cavity with a mass filled opacity confined to left upper zone and fibrotic changes in right upper zone [Figure 2]. Computed tomography of thorax revealed fibro-consolidation with cavitation in the anterior segment of left upper lobe, fibrotic nodule in both anterior and posterior segments of right the upper lobe [Figure 3]. Thus a possibility of aspergilloma with other possibilities was raised. The clinical examination of the rest of the system revealed no abnormality.
His blood biochemistry revealed total leucocyte count: 10,200/cmm, DLC: P 66 %, L 34 %. His PPD was 22 mm induration. His sputum for AFB on three consecutive days was positive. Thus a diagnosis of pulmonary tuberculosis was confirmed. For leprosy, patient consulted the skin department, was diagnosed with borderline lepromatous leprosy (on the basis of slit skin smear) with type-II Lepra reaction (biopsy of nodular lesion revealed diffuse sheets of foamy macrophages centered around adenexal structures with heavy infiltration of lepra bacilli suggestive of Erythema Nodosum Leprosum). He was advised to stop Dapsone and started oral Prednisolone, Thaliodomide and Clofazimine.
Thus a final diagnosis of borderline leprosy with type-II lepra reaction with concomitant pulmonary tuberculosis was made. The patient was referred to DOTS clinic and started on category-I treatment. The oral prednisolone was subsequently tapered and stopped while the other antileprotic drugs continued. The patient's general condition improved and was on regular follow-up.
| Discussion|| |
Leprosy and tuberculosis continue to be prevalent in our country. Prevalence of tuberculosis is estimated to be 4.0 and 16.0 per thousand for bacteriologically and radiologically active tuberculosis cases respectively, while the national prevalence rate of leprosy in India is 0.88/10,000.  The great attention about leprosy and tuberculosis coinfection was carried out by Chaussinand in 1948, and concluded that the prevalence of leprosy was inversely related with the prevalence of tuberculosis. In some leprosy communities, however, tuberculosis appears  to be quite common. This may be the result of a small group of people unable to defend against either organism. Leprosy has failed to return in areas where tuberculosis has been controlled, but this may be because other conditions have changed (e.g., because of the introduction of bacille Calmette- Guerin).
The principal means of transmission of both leprosy and tuberculosis is by aerosol spread. The incubation period in leprosy varies from six months to 40 years or longer, while in case of tuberculosis it is only four weeks.
Review of literature suggest that the occurrence of leprosy and tuberculosis coinfection first time reported by Relvich AL et al. in 1954 and strongly argued that association of tuberculoid form of leprosy with tuberculosis was uncommon.  Gajwani  et al. 1968 and Gupta  et al. 1971, reported the association of tuberculoid type of leprosy with tuberculosis. This was further supported by Agnihotri MS et al, in 1974, who documented three cases of tuberculoid leprosy with tuberculosis  and Nigam P et al, (1979), who documented two cases of tuberculoid leprosy in association with tuberculosis.  On the other hand, most of the cases of tuberculosis were associated with lepromatous leprosy followed by borderline lepromatous leprosy, as observed in present case also.
The duration of gap between the development of leprosy and tuberculosis varied between two months to 10-15 years, , the study with largest data showed gap duration of about 10-15 years, where duration of tuberculosis in most of the cases was within six months (while in present case it was 11 months). Only two cases of tuberculosis were found to occur earlier than leprosy, , where as one study concluded that tuberculosis can occur during full spectrum of leprosy. 
It is well known that tuberculosis infection can develop with certain risk factors likes HIV infection, low socioeconomic status, silicosis, diabetes mellitus, gastrectomy, renal failure, organ transplant; these have been incorporated in the risk stratification in tuberculosis guideline  (no such type of risk factor present in present case). There are also other purporated risk factors such as smoking; rheumatic disorders and use of low dose immunosuppressive agents or glucocorticosteroids but substantive epidemiological data about these risk factors factor tuberculosis are scarce.  In case of leprosy, corticosteroids are used primarily in the treatment of type I (reversal) reactions and type II reactions and silent neuropathy. Chandrashekhar et al. (2000), reported development of pulmonary tuberculosis after corticosteroid intake in two cases of leprosy.  Agarwal et al. (2000), reported a case of leprosy and tuberculosis coinfection in a patient of renal transplant recipient and who had taken prednisolone, azathiorpine and cyclosporine for more than nine years  (while in the present case, he received corticosteroid for >3 months). In leprosy, majority of the cases reported were pulmonary tuberculosis, while in two cases of extra-pulmonary tuberculosis (tuberculosis of larynx  and cutaeneous tuberculosis  ) were reported.
Diagnosis of leprosy was established in majority by slit skin smear but diagnosis by nasal smear and histopathological examination was also reported (while in present case by slit skin smear and biopsy also). Most common findings on chest radiographs were bilateral infiltrates ,,,, (as in the present case). Sputum smear for AFB was positive in majority of the cases with available data ,,,, (as in present case also).
Available data among three cases of leprosy with tuberculosis had lepra reaction including one of the author, in which one of them had type-II lepra reaction (ENL)  while one was type-I reversal reaction  (while in present case it was Type-II lepra reaction). Management of tuberculosis in leprosy coinfection does not change; with the same WHO treatment categorization i.e. Cat-I, Cat-II or Cat-III.
The detailed features of all the cases tuberculosis and leprosy coinfection and their comparison with present case are summarized in [Table 1]a and b.
| Conclusion|| |
It is very important to screen out the clinical features of tuberculosis, in each and every patient of leprosy to avoid single drug therapy (e.g. Rifampicin, which is a highly bactericidal first line anti-tubercular drug), which may contribute to development of acquired drug resistance and reduced effectiveness of anti- TB treatment.
| References|| |
|1.||Chaussinand R. Tuberculose et lepre, maladies antagoniques. Int J Lepr 1948;16:431-8. |
|2.||Long ER. Antagonism among diseases. Int J Lepr 1966;34:316-9. |
|3.||WHO. Current Leprosy prevalence in India: Factsheet, 2006. |
|4.||Donoghue HD, Marcsik A, Matheson C, Vernon K, Nuorala E, Molto JE, et al. Coinfection of Mycobacterium tuberculosis and Mycobacterium leprae in human archaeological samples: A possible explanation for the historical decline of leprosy. Proc Biol Sci 2005;272:389-94. [PUBMED] [FULLTEXT] |
|5.||Relvich AL. The treatment of tuberculosis in leprosy patients. Lepr Rev 1954;25:179-86. [PUBMED] [FULLTEXT] |
|6.||Gupta MC, Prasad M. Associated infection of pulmonary tuberculosis and leprosy. Indian J Med Sci 1971;25:183-5. |
|7.||Gajwani BW, Verma BS Marwaha RK Pande RS. Leprosy and tuberculosis. J Ass Phy Ind 1968;16:563. |
|8.||Agnihotri MS, Rastogi S, Agarwal RC. Tuberculosis and leprosy. Ind J Tub 1973;20:136-137. |
|9.||Nigam P, Dubey AL, Dayal SG, Goyal BM, Saxena HN, Samuel KC. The association of leprosy and pulmonary tuberculosis. Lepr India 1979;51:65-73. [PUBMED] [FULLTEXT] |
|10.||Agarwal DK, Mehta AR, Sharma AP, Sural S, Kumar A, Mehta B, et al. Coinfection with leprosy and tuberculosis in a renal transplant recipient. Nephrol Dial Transplant 2000;15:1720-1. [PUBMED] [FULLTEXT] |
|11.||Kumar B, Kaur S, Kataria S, Roy SN. Concomitant occurrence of leprosy and tuberculosis-A clinical, bacteriological and radiological evaluation. Lepr India 1982;54:671-6. [PUBMED] [FULLTEXT] |
|12.||Jick SS, Lieberman ES, Rahman MU, Choi HK. Glucocorticoid use, other associated factors, and the risk of tuberculosis. Arthritis and Rheumatism (Arthritis Care and Research) 2006;55:19-26. |
|13.||Targeted tuberculin testing and treatment of latent tuberculosis infection: Joint statement of the American Thoracic Society and the Centers for Disease Control and Prevention. Am J Respir Crit Care Med 2000;161:S221-47. |
|14.||Sreeramareddy CT, Menezes RG, Kishore PV. Concomitant age old infections of mankind - tuberculosis and leprosy: A case report. J Med Case Reports 2007;1:43. |
|15.||Inamadar AC, Sampagavi VV. Concomitant occurrence of leprosy, cutaneous tuberculosis and pulmonary tuberculosis--a case report. Lepr Rev 1994;65:282-4. [PUBMED] [FULLTEXT] |
|16.||Flanagan PM, McIlwain JC. Tuberculosis of the larynx in a lepromatous patient. J Laryngol Otol 1993;107:845-7. [PUBMED] |
|17.||Srilakshmi MA, Amit H, Lal J, Raveendranath S, Pais N. Concomitant infection with pulmonary tuberculosis and lepromatous leprosy. J Assoc Physicians India 2003;51:528-9. |
|18.||Lee HN, Embi CS, Vigeland KM, White CR Jr. Concomitant pulmonary tuberculosis and leprosy. J Am Acad Dermatol 2003;49:755-7. [PUBMED] [FULLTEXT] |
|19.||Vinnik LA, Pogorelov VN, Loginov VK. Leprosy and tuberculosis. Probl Tuberk 1971;49:39-44. |
|20.||Bhargava NC, Mathur KC. Simultaneous occurrence of leprosy and pulmonary tuberculosis. Indian J Chest Dis Allied Sci 1976;18:101-4. [PUBMED] [FULLTEXT] |
|21.||Gatner EM, Glatthaar E, Imkamp FM, Kok SH. Association of tuberculosis and leprosy in South Africa. Lepr Rev 1980;51:5-10. [PUBMED] [FULLTEXT] |
[Figure 1], [Figure 2], [Figure 3]
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