Home | About us | Editorial Board | Search | Ahead of print | Current Issue | Archives | Instructions | Online submissionContact Us   |  Subscribe   |  Advertise   |  Login  Page layout
Wide layoutNarrow layoutFull screen layout
Lung India Official publication of Indian Chest Society  
  Users Online: 708   Home Print this page  Email this page Small font size Default font size Increase font size
Year : 2010  |  Volume : 27  |  Issue : 2  |  Page : 66-71

Role played by Th2 type cytokines in IgE mediated allergy and asthma

Medical Research Society, Sir H. N. Hospital and Research Centre, Raja Ram Mohan Roy Road, Prathna Samaj, Girgaum, Mumbai - 400 004, India

Correspondence Address:
Sudha S Deo
Sr. Scientist. Medical Research Society, Sir H. N. Hospital and Research Centre, Raja Ram Mohan Roy Road, Prathna Samaj, Girgaum, Mumbai-400 004
Login to access the Email id

Source of Support: The Director and Management, Conflict of Interest: None

DOI: 10.4103/0970-2113.63609

Rights and Permissions

Objective: Recent evidence suggest that allergen type 2 helper T cells (Th2) play a triggering role in the activation/recruitment of IgE antibody producing B cells, mast cells and eosinophils. Reduced microbial exposure in early life is responsible for a shift of Th1/Th2 balance in the immune system towards the pre-allergic Th2 response. The Th1 predominantly produce IFNg and delayed type hypersensitivity while Th2 secrete IL-4, IL-5, IL-6, IL-13 and regulate B cell and eosinophil mediated responses. To assess regulatory changes in the immune system, in patients with allergy and asthma, we studied the cytokine profile in serum in comparison with normal healthy controls. Patients and Methods: A total of 170 patients with various allergies and asthmatic conditions were studied, for cytokines in the serum by ELISA using kits from Immunotech, and analyzed to identify the triggering factors or main contributors towards allergy and asthma. Results: Our study showed increase in the levels of IL-4, IL-5 and IL-6 in all groups which were non- significant. But the levels of IL-10, IL-13 and TNF α were highly significant. Besides, we found correlation of GM-CSF with IL-10. Significant correlation with different cytokines was observed. Most of these patients showed increase in IgE levels. Conclusions: This study gives a better understanding of how cytokines are the mediators of balance of Th1 and Th2 immune responses and IgE synthesis is controlled by cytokines. Further studies will eventually lead to improved treatment strategies in the clinical management of IgE mediated allergy.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded1187    
    Comments [Add]    
    Cited by others 9    

Recommend this journal