Home | About us | Editorial Board | Search | Ahead of print | Current Issue | Archives | Instructions | Online submissionContact Us   |  Subscribe   |  Advertise   |  Login  Page layout
Wide layoutNarrow layoutFull screen layout
Lung India Official publication of Indian Chest Society  
  Users Online: 1958   Home Print this page  Email this page Small font size Default font size Increase font size


 
  Table of Contents    
CASE REPORT
Year : 2012  |  Volume : 29  |  Issue : 2  |  Page : 179-181  

Giant solitary fibrous tumor pleura: Clinical dilemma and diagnosis


1 Department of Pathology, Military Hospital (Cardiothoracic Centre), Pune, Maharashtra, India
2 Department of Pathology, Armed Forces Medical College, Pune, Maharashtra, India
3 Department of Surgery, Military Hospital (Cardiothoracic Centre), Army Hospital (R and R), New Delhi, India
4 Department of Radiology, Military Hospital (Cardiothoracic Centre), Army Hospital (R and R), New Delhi, India

Date of Web Publication24-Apr-2012

Correspondence Address:
Amulyajit Kaur
Department of Pathology, Command Hospital (Western Command), Chandimandir-134 107
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0970-2113.95338

Rights and Permissions
   Abstract 

Solitary fibrous tumors in the lung are rare neoplasms with distinct clinicopathological and immunohistochemical features. We report a giant solitary fibrous tumor of the pleura in a young male which remained silent clinically till it assumed gigantic proportions. Histology and immunohistochemistry were classical of a solitary fibrous tumor. Inspite of its appalling size it proved to be benign in behavior. This case depicts the vulnerability of this lesion to a clinical bungle. The report highlights the significance of clinical suspicion of this rare neoplasm and reveals the diagnostic associations and procedures to avoid emperical therapy and delay in curative surgical treatment.

Keywords: Clubbing, giant solitary fibrous tumour, pleura


How to cite this article:
Kaur A, Gill SS, Singh J, Singh A, Mani NS. Giant solitary fibrous tumor pleura: Clinical dilemma and diagnosis. Lung India 2012;29:179-81

How to cite this URL:
Kaur A, Gill SS, Singh J, Singh A, Mani NS. Giant solitary fibrous tumor pleura: Clinical dilemma and diagnosis. Lung India [serial online] 2012 [cited 2019 Nov 14];29:179-81. Available from: http://www.lungindia.com/text.asp?2012/29/2/179/95338


   Introduction Top


Solitary fibrous tumors (SFT) of the pleura are rare tumors, comprising only 5% of pleural neoplasms. Literature reveals only two case series and a few solitary reports. [1] We report a unique case of a gigantic SFT presenting with low grade fever. The shadow caused by the tumor on plain X-ray chest suggested a pleural effusion. The patient was initially placed on antitubercular treatment. It was only when attempted pleural taps failed and help from the ultrasonologist was sought that information of the presence of a solid neoplasm mimicking pleural effusion on chest X-ray could be revealed. This illusory picture on X-ray chest has not yet been reported in literature and has a possibility of occurring in our country where facilities of higher specialized imaging techniques are resorted to sparingly in the periphery, mainly due to non availability and exorbitant costs involved.


   Case Report Top


A well-built 39- year old male presented with low-grade continuous fever over a period of 1 month and mild discomfort left lower side of the chest. On examination he was found to have low-grade fever, clubbing of nails, and absent breath sounds in the left infra-axillary and infrascapular regions. On investigating, hemoglobin and the blood counts were in normal range. ESR was 44 mm in the first hour. He was euglycemic; however X-ray chest [[Figure 1] inset] revealed features suggestive of a loculated pleural effusion with pleural thickening on the left side. Sputum for acid fast bacilli was negative. He was initially clinically diagnosed to have a tubercular effusion and antitubercular treatment was initiated. The patient however showed no response and guided tapping of the fluid was considered under ultrasonographic (USG) guidance. Ultra sonogram revealed a huge mass in the left pleural cavity abutting the chest wall. A USG-guided fine needle aspiration and trucut biopsy thereafter revealed a cellular but benign spindle cell neoplasm. A contrast-enhanced computerized tomogram demonstrated a large heterogeneous enhancing mass of soft tissue density in the left hemithorax. The mass appeared smooth, well-defined, and lobulated, with no evidence of chest wall or mediastinal invasion, or significant associated mediastinal shift [Figure 1]. The visualized angle of contact with the pleura on the chest PA radiograph appears obtuse, while on the CT, the angle formed with the lateral chest wall is acute. An obtuse angle suggests that the organ of origin is pleura; however in large, benign masses this angle does not necessarily have to be obtuse. Subsequently the mass was resected via thoracotomy.
Figure 1: Contrast enhanced computed tomogram showing a huge mass in the left hemithorax. X-ray chest PA view (inset) providing an impression of a loculated pleural effusion

Click here to view


Gross examination revealed an encapsulated solid tumor with the bosselated nodular surface weighing 2 kg. The cut section showed a solid fleshy mass with vague whorling measuring 23 × 21 × 09 cm [Figure 2]. The peripheral subcapsular area showed an increased density of blood vessels. Pericapsular adherent lung and pleural tissue was present in some areas.
Figure 2: Cut section of the excised tumor revealing an encapsulated solid fleshy mass with whorling

Click here to view


Microscopy revealed an encapsulated spindle cell neoplasm of varying cellularity [Figure 3]. There were occasional focal areas of ischemic subcapsular hemorrhage and necrosis. The less cellular areas contained spindle cells enmeshed in collagen bundles and the cellular areas comprising cells with round to ovoid nuclei with a fine chromatin pattern and pale eosinophilic cytoplasm. Occasional foci of typical mitosis were seen (maximum number of 03-4/HPF). Perivascular cuffs of hyalinization and areas with increased vascularity were noticed. A sparse sprinkling of lymphomononuclear cells was also observed.
Figure 3: Photomicrographs of the neoplasm showing (a) Subcapsular increased vascularity (H and E, ×200), (b) Cellular areas with relatively plump spindle cells and an occasional mitosis (H and E, ×400), (c) Parvicellular spindle cell areas, (H and E, ×400), (d) Variably hyalinised collagenous stroma, hyaline cuffs around vessels, and microcystic degeneration, (H and E, ×200)

Click here to view


Immunohistochemistry revealed a strong diffuse positivity for CD34 (+++), Vimentin (++) and SMA (++) [Figure 4]. F-VIIIAg showed mild (+) focal staining in some tumor cells. Epithelial membrane antigen and bcl-2 were negative (labvision, prediluted). This confirmed the diagnosis of a solitary fibrous tumor.
Figure 4: Immunohistochemical profile showing (a, c, d) Diffuse positivity for CD34, vimentin, and SMA. (b) FVIIIAg immunohistochemistry revealed mild-sparse positivity with normal staining of vessels within the tumor. (DAB×200)

Click here to view



   Discussion Top


Solitary fibrous tumors of the pleura (SFTP) are rare primary tumors, histogenesis of which has been a controversial issue. They have been given varying nomenclatures such as localized pleural mesothelioma, pleural fibroma, localized fibrous mesothelioma, submesothelial fibroma, and localized fibrous tumor. [2] However they are now considered to arise from the submesothelial areolar mesenchyme. Immunohistochemistry and electron microscopy have led to these neoplasms being named as solitary fibrous tumors. [3] Cytogenetic data, although limited, have shown various abnormal karyotypes and supernumerary chromosome 8 has suggested malignant behavior of the tumor. [4],[5] SFTP occurs in a wide age range (5-87 years) with a fairly equal frequency in both sexes. [6] Most of these arise from the parietal pleura and are exophytic, sometimes attached by a stalk. Occasionally those that are sessile appear to grow inward into the lung parenchyma leading to a clinical suspicion of a malignant mass. Most patients are asymptomatic and come to notice incidently. Our patient had developed atelectasis of the surrounding lung with low to moderate grade fever possibly due to supervening infection. He was suspected to have tuberculosis and was being investigated for the same when radiological imaging beyond an X-ray chest confirmed the mass. These tumors are now known to have accompanying paraneoplastic syndromes. Hypertrophic pulmonary osteoarthropathy (HPO) has been found to be the most common paraneoplastic syndrome in SFTP. [7] Hypertrophic pulmonary osteoarthropathy, possibly caused by ectopic GH like substance, is reported in up to 22% of patients (especially in tumors over 7 cm in diameter) compared to a 5% incidence in lung carcinoma. The patient being reported upon had prominent clubbing. Osseous radiographic changes and the HPO may take months to resolve after tumor resection. Recurrence of symptoms may herald recurrence of the tumor. Severe symptomatic hypoglycemia has also been reported in these patients incidence of which ranges from 3% to 4%. [1],[2]

Histologically these exhibit a morphology of a low-grade spindle cell neoplasm. [8] The main differential diagnoses in this case were of an inflammatory myofibroblastic tumor (IMT) and a sclerosing hemangioma (SH). The inflammatory component classical of an IMT was not seen. Focal areas possessing an apparent vascular pattern and microcystic degeneration led to the suspicion of a SH. Immunohistochemistry however confirmed a solitary fibrous tumor.

These tumors prove to be benign in behavior and resection is considered curative with cure rates ranging from 88% to 92%. About 8% of these are reported to recur which has been related to an increased mitosis (more than 4/10 HPF). [9] These tumors may assume alarming proportions; however, the size has been reported to not to have any bearing on its being malignant, resectable or curable. [10]

The case being reported is unique for the purpose of rarity of these neoplasms, occurrence in a relatively young age, and the accompanying HPO. The case also highlights the significance of imaging modalities beyond a simple X-ray chest to avoid an erroneous diagnosis and therapy which could lead to unnecessary increased morbidity for the patient. This would only be possible by keeping a high index of suspicion in an appropriate clinical background.

 
   References Top

1.Cardillo G, Facciolo F, Cavazzana AO, Capece G, Gasparri R, Martelli M. Localized (solitary) fibrous tumors of the pleura: An analysis of 55 patients. Ann Thorac Surg 2000;70:1808-12.  Back to cited text no. 1
    
2.De Perrot M, Fischer S, Brundler MA, Sekine Y, Keshavjee S. Solitary fibrous tumors of the pleura. Ann Thorac Surg 2002;74:285-93 .  Back to cited text no. 2
    
3.Yousem SA, Flynn SD. Intrapulmonary localized fibrous tumor. Intraparenchymal so-called localized fibrous mesothelioma. Am J Clin Pathol 1988;89:365-9.  Back to cited text no. 3
    
4.Torabi A, Lele SM, DiMaio D, Pinnt JC, Hess MM, Nelson M, et al. Lack of a common or characteristic cytogenetic anomaly in solitary fibrous tumor. Cancer Genet Cytogenet 2008;181:60-64.  Back to cited text no. 4
    
5.De Leval L, Defraigne JO, Hermans G, Dôme F, Boniver J, Herens C. Malignant solitary fibrous tumor of the pleura: Report of a case with cytogenetic analysis. Virchows Arch 2003;442:388-92.  Back to cited text no. 5
    
6.Shields TW, Yeldandi AV. Localized fibrous tumors of the pleura. In: Shields TW, Locicero III J, Ponn RB, Rusch VW, editors. General thoracic surgery. 6 th ed. Philadelphia, PA: Lippincott Williams and Wilkins; 2005:889-900.  Back to cited text no. 6
    
7.Briselli M, Mark EJ, Dickersin GR. Solitary fibrous tumors of the pleura: Eight new cases and review of 360 cases in the literature. Cancer 1981;47:2678-89.  Back to cited text no. 7
    
8.Granville L, Laga AC, Allen TC, Dishop M, Roggli VL, Churg A, et al. Review and update of uncommon primary pleural tumors: A practical approach to diagnosis. Arch Pathol Lab Med 2005;129:1428-1443  Back to cited text no. 8
    
9.Corrin B, Nicholson AG, Burke MM. Pathology of the lung. 2 nd ed. Philadelphia: Churchill Livingstone Elsevier; 2006:714-16.  Back to cited text no. 9
    
10.Bar I, Papiashvilli M, Zukerman B, Stav D, Sandbank J. Large solitary fibrous tumour of the pleura: analysis of six cases. Heart Lung Circ 2007;16:282-4.  Back to cited text no. 10
    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4]


This article has been cited by
1 Giant benign solitary fibrous tumour of the pleura (> 15 cm): Role of radiological pathological correlations in management. Report of 3 cases and review of the literature
Pusiol, T., Piscioli, I., Scialpi, M., Hanspeter, E.
Pathologica. 2013; 105(3): 77-82
[Pubmed]
2 Role of computed tomography in the preoperative diagnosis of giant benign solitary fibrous tumor pleura
Pusiol, T. and Scialpi, M.
Lung India. 2013; 30(1): 82-85
[Pubmed]



 

Top
  
 
  Search
 
  
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
    Abstract
   Introduction
   Case Report
   Discussion
    References
    Article Figures

 Article Access Statistics
    Viewed2651    
    Printed77    
    Emailed1    
    PDF Downloaded345    
    Comments [Add]    
    Cited by others 2    

Recommend this journal