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Year : 2012  |  Volume : 29  |  Issue : 3  |  Page : 305  

The lungs and drug delivery

Department of Lung, Chemical Injury Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

Date of Web Publication28-Jul-2012

Correspondence Address:
Amin Saburi
Department of Lung, Chemical Injury Research Center, Baqiyatallah University of Medical Sciences, Tehran
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0970-2113.99136

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How to cite this article:
Shohrati M, Saburi A, Ghanei M. The lungs and drug delivery. Lung India 2012;29:305

How to cite this URL:
Shohrati M, Saburi A, Ghanei M. The lungs and drug delivery. Lung India [serial online] 2012 [cited 2020 Jul 3];29:305. Available from: http://www.lungindia.com/text.asp?2012/29/3/305/99136


We read with interest Patil JS, Sarasija's paper entitled "Pulmonary drug delivery strategies: A concise, systematic review" published in Lung India; 2012 Jan; 29(1):44-9. [1] They expertly reviewed literatures and discussed about the physiological (such as mechanism of epithelial cell transport), technical (focusing on excipients and devices which were used, and techniques of particulate dosage production), and efficacy aspects of novel pulmonary drug delivery. We think if some points were discussed, the review could be more perfect.

Micelle, and also liposome as a composite micelle, is a collection of surfactant molecules composed of a hydrophilic head and a hydrophobic tail in the micelle centre. These structures and also its inverted form are able to carry drug across the cell or other biological membranes without any biologic disturbance or drug destruction. Therefore, their use is rapidly expanding, especially for drug delivery to the lungs. [2] Chitosan, one of the most famous and commonly used micelle, was recently used as nanoparticle to deliver drug to the lungs, especially for drugs with high first pass phenomena such as isoniazid. [3] Also, a sustained delivery to the respiratory system by Chitosan-based spray-dried powders was used safely and also it was recommended for delivering drugs (such as protein-based drugs), which should be delivered to the special cells and it can be an instrumental strategy. [4],[5]

On the other hand, other drug delivering strategies such as transdermal delivery should be considered in this issue. It seems that several problems associated with pulmonary route, which it can be effective on the drug delivery (such as difficulty in use especially for children and other patients with poor co-operation), will be solved if this route be used. Therapeutic dermal patches were widely used for cardiovascular diseases and the drug can reach to the systemic circulation with bypassing the intestinal-hepatic circulation and it can be future strategies to drug delivery. Although using hydrophobic polymers in dermal patch increase its efficacy, [6] further investigations were needed to enhance hydrophobic or hydrophilic drugs to deliver effectively via percutaneous administration.

   References Top

1.Patil JS, Sarasija S. Pulmonary drug delivery strategies: A concise, systematic review. Lung India 2012;29:44-9.  Back to cited text no. 1
[PUBMED]  Medknow Journal  
2.Grenha A, Remuñán-López C, Carvalho EL, Seijo B. Microspheres containing lipid/chitosan nanoparticles complexes for pulmonary delivery of therapeutic proteins. Eur J Pharm Biopharm 2008;69:83-93.  Back to cited text no. 2
3.Pourshahab PS, Gilani K, Moazeni E, Eslahi H, Fazeli MR, Jamalifar H. Preparation and characterization of spray dried inhalable powders containing chitosan nanoparticles for pulmonary delivery of isoniazid. J Microencapsul 2011;28:605-13.  Back to cited text no. 3
4.Grenha A, Seijo B, Remunan-Lopez C. Microencapsulated chitosan nanoparticles for lung protein delivery. Eur J Pharm Sci 2005;25:427-37.  Back to cited text no. 4
5.Learoyd TP, Burrows JL, French E, Seville PC. Sustained delivery by leucine-modified chitosan spray-dried respirable powders. Int J Pharm 2009;372:97-104.  Back to cited text no. 5
6.Baviskar DT, Parik VB, Gupta HN, Maniyar AH, Jain DK. Design and evaluation of patches for transdermal delivery of losartan potassium. PDA J Pharm Sci Technol 2012;66:126-35.  Back to cited text no. 6


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