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Lung India Official publication of Indian Chest Society  
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Year : 2014  |  Volume : 31  |  Issue : 3  |  Page : 282-284

Pulmonary alveolar proteinosis due to mycophenolate and cyclosporine combination therapy in a renal transplant recipient

1 Department of Pulmonary Medicine, Owaisi Hospital and Research Centre; Department of Pulmonology, Care Hospitals, Banjara Hills, Hyderabad, India
2 Department of Nephrology, Owaisi Hospital and Research Centre, Hyderabad, India
3 Department of Pulmonology, Care Hospitals, Banjara Hills, Hyderabad, India

Correspondence Address:
Prof. Ashfaq Hasan
6-3-248/3/A, Flat 1E, Maruthi Heights, Road No 1, Banjara Hills, Hyderabad - 500 034, Andhra Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0970-2113.135782

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Pulmonary alveolar proteinosis (PAP) is an orphan disease characterized by the accumulation of excess of surfactant within alveoli and bronchioles. The primary form of PAP (P-PAP; also referred to as idiopathic or autoimmune) is the most common form. It is mediated through a circulating neutralizing antibody against granulocyte-macrophage colony-stimulating factor. Secondary PAP (S-PAP) can be induced by a host of inciting agents and is far more liable to progress to terminal respiratory failure. We describe a rare case of S-PAP occurring in a renal transplant recipient due to mycophenolate and cyclosporine combination-therapy, which resolved spontaneously following withdrawal of these drugs.

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