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Year : 2014  |  Volume : 31  |  Issue : 4  |  Page : 433-434  

Adenosine deaminase in exudative pleural effusions

1 Bangkok, Thailand
2 Department of Medicine, University of Nis, Nis, Serbia

Date of Web Publication1-Oct-2014

Correspondence Address:
Viroj Wiwanitkit
Department of Medicine, University of Nis, Nis
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0970-2113.142114

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How to cite this article:
Wiwanitkit S, Wiwanitkit V. Adenosine deaminase in exudative pleural effusions. Lung India 2014;31:433-4

How to cite this URL:
Wiwanitkit S, Wiwanitkit V. Adenosine deaminase in exudative pleural effusions. Lung India [serial online] 2014 [cited 2020 Jul 5];31:433-4. Available from: http://www.lungindia.com/text.asp?2014/31/4/433/142114


The report on 'Adenosine Deaminase in Exudative Pleural Effusions' is very interesting. [1] Mehta et al. have concluded that 'pleural fluid adenosine deaminase (ADA) is cost-effective and a good screening test for the diagnosis of tuberculosis (TB)'. [1] This conclusion must be carefully considered. First, the reported predictive values of the test, in the present report, are not good. [1] This finding is similar to that of a previous report by Khow-Ean et al. [2] As Islam et al. have noted, the test must be used along with the conventional method to get a diagnosis. [3] Khan et al. have also reported that the use of pleural fluid interferon-gamma can provide a better diagnostic result than ADA. [4] Second, Mehta et al. have not performed any analysis for cost-effectiveness, hence, the conclusion on cost-effectiveness may not be possible. A good report that has considered the cost-effectiveness analysis of using ADA is the previous report by Sharma et al. [5]

   References Top

1.Mehta AA, Gupta AS, Ahmed S, Rajesh V. Diagnostic utility of adenosine deaminase in exudative pleural effusions. Lung India 2014;31:142-4.  Back to cited text no. 1
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2.Khow-Ean N, Booraphun S, Aekphachaisawat N, Sawanyawisuth K. Adenosine deaminase activity level as a tool for diagnosing tuberculouspleuraleffusion.Southeast Asian J Trop Med Public Health 2013;44:655-9.  Back to cited text no. 2
3.Islam A, Hossain MA, Paul SK, Bhuiyan MR, Khan RA, Rahman MM, et al. Role of adenosine deaminase in diagnosis of tubercular pleural effusion.Mymensingh Med J 2014;23:24-7.  Back to cited text no. 3
4.Khan FY, Hamza M, Omran AH, Saleh M, Lingawi M, Alnaqdy A, et al. Diagnostic value ofpleuralfluidinterferon-gamma and adenosine deaminase in patients with pleural tuberculosis in Qatar. Int J Gen Med 2013;6:13-8.  Back to cited text no. 4
5.Sharma SK, Banga A. Pleuralfluidinterferon-gamma and adenosine deaminase levels intuberculosis pleural effusion: A cost-effectiveness analysis. J Clin Lab Anal 2005;19:40-6.  Back to cited text no. 5


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