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Year : 2014  |  Volume : 31  |  Issue : 4  |  Page : 434  

Author's reply

Department of Pulmonary Medicine, Amrita Institute of Medical Sciences, Kochi, Kerala, India

Date of Web Publication1-Oct-2014

Correspondence Address:
Asmita Anilkumar Mehta
Department of Pulmonary Medicine, Amrita Institute of Medical Sciences, Kochi, Kerala
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Source of Support: None, Conflict of Interest: None

PMID: 25378870

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How to cite this article:
Mehta AA, Gupta AS, Ahmed S, Venkitakrishnan R. Author's reply. Lung India 2014;31:434

How to cite this URL:
Mehta AA, Gupta AS, Ahmed S, Venkitakrishnan R. Author's reply. Lung India [serial online] 2014 [cited 2020 May 28];31:434. Available from: http://www.lungindia.com/text.asp?2014/31/4/434/142116

We would like to thank Wiwanitkit et al., for their interest in our study and their valuable observations.

In response to the authors' comments about the reported lower predictive value of the adenosine deaminase (ADA) test in our article, [1] we want to clarify that as per our study, ADA is a valuable test to differentiate malignancy from TB. Our study showed that only three (8%) out of 36 cases of malignant pleural effusion had ADA ≥40 U/l.

We agree with the authors' comments that ADA must be used along with the conventional method to get a diagnosis, as suggested by Islam et al. [2]

Khan et al. [3] has showed that use of the pleural fluid interferon-gamma can provide a better diagnostic result than ADA, but at a higher cost. [3] We would also like to quote from the meta-analysis by Greco et al., which showed that the joint sensitivity and specificity of ADA (93%) was similar to IFN-γ (96%) and no significant difference was present in the performance of both the tests in the diagnosis of TB pleurisy. [4]

We accept that we have not conducted a cost-effectiveness analysis for our study, [1] and it is improper to state in conclusion that the ADA test is cost-effective. Despite what has just been stated, it has been seen that the ADA test is less expensive than other invasive tests like the thoracoscopy-guided or blind pleural biopsy.

   References Top

1.Mehta AA, Gupta AS, Ahmed S, Rajesh V. Diagnostic utility of adenosine deaminase in exudative pleural effusions. Lung India 2014;31:142-4.  Back to cited text no. 1
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2.Islam A, Hossain MA, Paul SK, Bhuiyan MR, Khan RA, Rahman MM, et al. Role of adenosine deaminase in diagnosis of tubercularpleuraleffusion.Mymensingh Med J 2014;23:24-7.  Back to cited text no. 2
3.Khan FY, Hamza M, Omran AH, Saleh M, Lingawi M, Alnaqdy A, et al. Diagnostic value of pleural fluid interferon-gamma and adenosinedeaminase in patients with pleural tuberculosis in Qatar. Int J Gen Med 2013;6:13-8.  Back to cited text no. 3
4.Greco S, Girardi E, Masciangelo R, Capoccetta GB, Saltini C. Adenosine deaminase and interferon gamma measurements for the diagnosis of tuberculous pleurisy: A meta-analysis. Int J Tuberc Lung Dis 2003;7:777-86.  Back to cited text no. 4


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