|LETTER TO EDITOR
|Year : 2016 | Volume
| Issue : 1 | Page : 114
Phagocytic activity of neutrophils in chronic obstructive pulmonary disease
Baishakhi Ghosh1, Kanchan Pyasi2
1 Molecular Respiratory Research Laboratory, Chest Research Foundation; Faculty of Health and Biomedical Science, Symbiosis International University, Pune, India
2 Molecular Respiratory Research Laboratory, Chest Research Foundation, Pune, India
|Date of Web Publication||4-Jan-2016|
Molecular Respiratory Research Laboratory, Chest Research Foundation; Faculty of Health and Biomedical Science, Symbiosis International University, Pune
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Ghosh B, Pyasi K. Phagocytic activity of neutrophils in chronic obstructive pulmonary disease. Lung India 2016;33:114
We read the article by Shanmugam et al. with great interest. In this study, the authors have assessed the phagocytic activity of neutrophils from peripheral blood in chronic obstructive pulmonary disease (COPD) subjects. For this study, the study group involved 28 clinically and spirometrically proven COPD subjects and the control group involved 25 healthy subjects.
The alcoholic population in study were 25% and 7% in study group and control group respectively. Prior animal study has reported that alcohol intoxication can impair bacterial phagocytosis of neutrophils. It is possible that the observation of phagocytic impairment of neutrophil is an additive effect of alcohol consumption and not COPD condition alone. Shanmugam et al. could have analyzed the phagocytic activity of the alcoholic population separately, or they could have been excluded from the study.
The control group involved a heterogeneous population of both smokers and nonsmokers. The authors could have possibly assessed the phagocytic activity among healthy sub-groups (smokers and nonsmokers) as well; because prior studies have reported that phagocytic activity of smokers is less compared to nonsmokers.
Prior studies have revealed that neutrophil phagocytosis is not altered in COPD, which is in opposition to the finding of Shanmugam et al.
The authors could have shown the actual values of lung function tests, as this would have made the results easy to comprehend. Furthermore, the authors could have possibly correlated the neutrophilic phagocytic activity with lung function data, as this would provide a better understanding of the pathogenesis of disease.
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Conflicts of interest
There are no conflicts of interest.
| References|| |
Shanmugam L, Johnson P, Ravinder S, Padmavathi R, Rajagopalan B, Kindo A. Assessment of phagocytic activity of neutrophils in chronic obstructive pulmonary disease. Lung India 2015;32:437.
Zhang P, Nelson S, Summer WR, Spitzer JA. Acute ethanol intoxication suppresses the pulmonary inflammatory response in rats challenged with intrapulmonary endotoxin. Alcohol Clin Exp Res 1997;21:773-8.
Güntsch A, Erler M, Preshaw PM, Sigusch BW, Klinger G, Glockmann E. Effect of smoking on crevicular polymorphonuclear neutrophil function in periodontally healthy subjects. J Periodontal Res 2006;41:184-8.
Walton GM, Purvis T, Chadwick C, Stockley RA, Sapey E. S46 phagocytosis by blood neutrophils is not attenuated in patients with chronic obstructive pulmonary disease. Thorax 2014;69 Suppl 2:A26-7.