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LETTER TO EDITOR
Year : 2016  |  Volume : 33  |  Issue : 1  |  Page : 114  

Phagocytic activity of neutrophils in chronic obstructive pulmonary disease


1 Molecular Respiratory Research Laboratory, Chest Research Foundation; Faculty of Health and Biomedical Science, Symbiosis International University, Pune, India
2 Molecular Respiratory Research Laboratory, Chest Research Foundation, Pune, India

Date of Web Publication4-Jan-2016

Correspondence Address:
Baishakhi Ghosh
Molecular Respiratory Research Laboratory, Chest Research Foundation; Faculty of Health and Biomedical Science, Symbiosis International University, Pune
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0970-2113.173080

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How to cite this article:
Ghosh B, Pyasi K. Phagocytic activity of neutrophils in chronic obstructive pulmonary disease. Lung India 2016;33:114

How to cite this URL:
Ghosh B, Pyasi K. Phagocytic activity of neutrophils in chronic obstructive pulmonary disease. Lung India [serial online] 2016 [cited 2019 Jun 16];33:114. Available from: http://www.lungindia.com/text.asp?2016/33/1/114/173080

Sir,

We read the article by Shanmugam et al.[1] with great interest. In this study, the authors have assessed the phagocytic activity of neutrophils from peripheral blood in chronic obstructive pulmonary disease (COPD) subjects. For this study, the study group involved 28 clinically and spirometrically proven COPD subjects and the control group involved 25 healthy subjects.

The alcoholic population in study were 25% and 7% in study group and control group respectively. Prior animal study has reported that alcohol intoxication can impair bacterial phagocytosis of neutrophils.[2] It is possible that the observation of phagocytic impairment of neutrophil is an additive effect of alcohol consumption and not COPD condition alone. Shanmugam et al. could have analyzed the phagocytic activity of the alcoholic population separately, or they could have been excluded from the study.

The control group involved a heterogeneous population of both smokers and nonsmokers. The authors could have possibly assessed the phagocytic activity among healthy sub-groups (smokers and nonsmokers) as well; because prior studies have reported that phagocytic activity of smokers is less compared to nonsmokers.[3]

Prior studies have revealed that neutrophil phagocytosis is not altered in COPD,[4] which is in opposition to the finding of Shanmugam et al.[1]

The authors could have shown the actual values of lung function tests, as this would have made the results easy to comprehend. Furthermore, the authors could have possibly correlated the neutrophilic phagocytic activity with lung function data, as this would provide a better understanding of the pathogenesis of disease.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

 
   References Top

1.
Shanmugam L, Johnson P, Ravinder S, Padmavathi R, Rajagopalan B, Kindo A. Assessment of phagocytic activity of neutrophils in chronic obstructive pulmonary disease. Lung India 2015;32:437.  Back to cited text no. 1
  Medknow Journal  
2.
Zhang P, Nelson S, Summer WR, Spitzer JA. Acute ethanol intoxication suppresses the pulmonary inflammatory response in rats challenged with intrapulmonary endotoxin. Alcohol Clin Exp Res 1997;21:773-8.  Back to cited text no. 2
    
3.
Güntsch A, Erler M, Preshaw PM, Sigusch BW, Klinger G, Glockmann E. Effect of smoking on crevicular polymorphonuclear neutrophil function in periodontally healthy subjects. J Periodontal Res 2006;41:184-8.  Back to cited text no. 3
    
4.
Walton GM, Purvis T, Chadwick C, Stockley RA, Sapey E. S46 phagocytosis by blood neutrophils is not attenuated in patients with chronic obstructive pulmonary disease. Thorax 2014;69 Suppl 2:A26-7.  Back to cited text no. 4
    




 

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