Home | About us | Editorial Board | Search | Ahead of print | Current Issue | Archives | Instructions | Online submissionContact Us   |  Subscribe   |  Advertise   |  Login  Page layout
Wide layoutNarrow layoutFull screen layout
Lung India Official publication of Indian Chest Society  
  Users Online: 997   Home Print this page  Email this page Small font size Default font size Increase font size

  Table of Contents    
Year : 2016  |  Volume : 33  |  Issue : 2  |  Page : 232-233  

Tuberculosis and pulmonary hypertension: Commentary

Department of Respiratory Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India

Date of Web Publication25-Feb-2016

Correspondence Address:
Ajay Kumar Verma
Department of Respiratory Medicine, King George's Medical University, Lucknow, Uttar Pradesh
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0970-2113.177455

Rights and Permissions

How to cite this article:
Verma AK. Tuberculosis and pulmonary hypertension: Commentary. Lung India 2016;33:232-3

How to cite this URL:
Verma AK. Tuberculosis and pulmonary hypertension: Commentary. Lung India [serial online] 2016 [cited 2020 Feb 24];33:232-3. Available from: http://www.lungindia.com/text.asp?2016/33/2/232/177455

Pulmonary hypertension (PH) is a hemodynamic and pathophysiological condition, defined as an increase in mean pulmonary arterial pressure >25 mm Hg at rest as assessed by right heart catheterization (RHC).[1] According to the Dana Point (2008) classification of PH,[2] Group 1 PH is known as pulmonary arterial hypertension (PAH), which includes idiopathic PAH (IPAH), heritable, drug-induced and associated with PAH groups. Overall, PAH is a rare disease. Although worldwide prevalence rates are not known, overall prevalence in European countries has been reported as 15–50 cases per million population.[3] The other Groups 2–5 of PH are comparatively more common, although data are lacking. PH due to pulmonary causes, which are clubbed together as Group 3, is one of the most common causes of PH and eventually cor pulmonale. The diseases included in this group are chronic obstructive pulmonary disease, interstitial lung diseases, obstructive sleep apnea, combined emphysema and fibrosis, chronic pulmonary thromboembolism and high altitude residence.[2]

Pulmonary tuberculosis (TB) has not been cited as a cause for the development of PH in western literature. In India, on the other hand, being a high burden country, it is not unusual to find patients who have been treated for pulmonary TB to present with features of right heart failure. The possible causes for the development of PH in these patients are the destruction of vascular bed due to parenchymal abnormalities, vasculitis, and endarteritis, leading to reduced cross-sectional area of the pulmonary vasculature.[4],[5] The common presentation of these patients include dyspnea out of proportion to their radiological picture, desaturation at even mild exertion and sometimes as overt heart failure with pedal edema, raised jugular venous pressure and tender hepatomegaly. Indian data on the prevalence of PH in patients with pulmonary TB is limited.[6],[7],[8] It is prudent to undertake such studies, as it will be helpful in understanding the exact pathophysiology and timely intervention can be done before the development of PH, as it portends a poor prognosis.

In this issue of the journal, Bhattacharya et al. reported PH in patients with tuberculosis.[9] This study has its drawbacks. The number of subjects in the study is too little to generalize the results in a population. Second, it has not been mentioned whether these patients are sputum smear positive at the time of study or have been previously treated for pulmonary TB. Not using RHC for the diagnosis of PH is another shortcoming. Furthermore, functional assessment of patients should have been done through a more composite scoring system than CAT, for proper analysis.

Despite this, such studies need to be encouraged at all tertiary care centers with facilities for RHC and other relevant investigations so that nation-wide data can be collected regarding the existence of PH in treated cases of pulmonary TB. These patients present with worsening dyspnea and are incorrectly diagnosed as relapse of TB and are started on anti-TB treatment or are prescribed inhaled bronchodilators without performing spirometry or documenting airflow obstruction. It is imperative to avoid such mismanagement. Furthermore, adequate and timely management of pulmonary TB would prevent the development of PH and ultimately cor pulmonale, which significantly reduces the quality of life as well as shortens survival.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

   References Top

D'Alonzo GE, Barst RJ, Ayres SM, Bergofsky EH, Brundage BH, Detre KM, et al. Survival in patients with primary pulmonary hypertension. Results from a national prospective registry. Ann Intern Med 1991;115:343-9.  Back to cited text no. 1
Simonneau G, Robbins IM, Beghetti M, Channick RN, Delcroix M, Denton CP, et al. Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol 2009;54 1 Suppl: S43-54.  Back to cited text no. 2
Peacock AJ, Murphy NF, McMurray JJ, Caballero L, Stewart S. An epidemiological study of pulmonary arterial hypertension. Eur Respir J 2007;30:104-9.  Back to cited text no. 3
Ferrer MI. Cor pulmonale (pulmonary heart disease): Present-day status. Am Heart J 1975;89:657-64.  Back to cited text no. 4
Fishman AP. State of the art: Chronic cor pulmonale. Am Rev Respir Dis 1976;114:775-94.  Back to cited text no. 5
Kapoor SC. Pulmonary hypertension in pulmonary tuberculosis. Indian J Tuberc 1950;6:50-64.  Back to cited text no. 6
Patel V, Khaped K, Solanki B, Patel A, Rathod H, Patel J. Profile of pulmonary hypertension patients coming to civil hospital, Ahmedabad. Int J Res Med 2013;2:94-7.  Back to cited text no. 7
Ahmed AE, Ibrahim AS, Elshafie SM. Pulmonary hypertension in patients with treated pulmonary tuberculosis: Analysis of 14 consecutive cases. Clin Med Insights Circ Respir Pulm Med 2011;5:1-5.  Back to cited text no. 8
Bhattacharyya P, Saha D, Bhattacherjee PD, Das SK, Bhattacharyya PP, Dey R. Tuberculosis associated pulmonary hypertension: The revelation of a clinical observation. Lung India 2016;33:??-??.  Back to cited text no. 9


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article

 Article Access Statistics
    PDF Downloaded294    
    Comments [Add]    

Recommend this journal