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CASE LETTER
Year : 2019  |  Volume : 36  |  Issue : 4  |  Page : 360-361  

Multiple calcific opacities on a chest radiograph


Department of Pulmonary Medicine, ESI PGIMSR, Model Hospital, Mumbai, Maharashtra, India

Date of Web Publication28-Jun-2019

Correspondence Address:
Dr. Ivona Lobo
Department of Pulmonary Medicine, ESI PGIMSR, Model Hospital, Mumbai, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/lungindia.lungindia_118_18

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How to cite this article:
Dumne P, Lobo I, Pawar R, Tayade S. Multiple calcific opacities on a chest radiograph. Lung India 2019;36:360-1

How to cite this URL:
Dumne P, Lobo I, Pawar R, Tayade S. Multiple calcific opacities on a chest radiograph. Lung India [serial online] 2019 [cited 2019 Jul 21];36:360-1. Available from: http://www.lungindia.com/text.asp?2019/36/4/360/261696



Sir,

A 63-year-old male who was undergoing preoperative evaluation was referred for an abnormal chest radiograph with multiple calcific opacities. He did not give any history of having pulmonary tuberculosis in the past. He had no respiratory symptoms. He gave history of working in an asbestos factory for 5 years around 20 years ago.

Chest radiograph showed multiple bilateral calcified pleural plaques with sparing of both costophrenic angles [Figure 1]. This irregular thickened nodular edge of calcified pleural plaques had the appearance of a holly leaf [Figure 2], so called “holly leaf sign.”[1] “Geographic density” is another common term used to describe this appearance.
Figure 1: Chest radiograph shows irregular thickened nodular edges of calcified pleural plaques resembling holly leaf. Costophrenic angles and apices are spared

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Figure 2: Holly leaf showing typical margins

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Radiologically, asbestos pleural plaques are usually seen bilaterally in 80% of cases. They are focal areas of pleural thickening generally affecting parietal pleura mostly seen on posterolateral chest wall between the seventh and tenth ribs, lateral chest wall between the sixth and ninth ribs, the dome of the diaphragm (virtually pathognomonic) where they follows rib contour and diaphragm.[2] Sometimes, they enter lobar fissure and invade mediastinal pleura. Both apices and costophrenic angles are typically spared. Calcification is seen in approximately 5%–15% of patients.[3]

Computed tomographic (CT) scan is more sensitive for visualization of anterior and paravertebral plaques that are not well demonstrated at chest radiography [Figure 3]c.[3] Diaphragmatic pleural plaques have a variety of contours [Figure 3]b, but a classic example is a protuberance resembling a mushroom cap [Figure 3]a which is virtually diagnostic of prior asbestos exposure.
Figure 3: Diaphragmatic pleural plaques (b) having a protuberance resembling a mushroom cap which is diagnostic of asbestos exposure. (a) Anterior and paravertebral plaques that are not visualized on a chest radiograph (c)

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Asbestos exposure causes wide range of pulmonary manifestations, benign, being pleural plaques, pleural effusion, asbestosis, and malignancies such as lung cancer and malignant mesothelioma. Pleura is more sensitive than parenchyma for asbestos exposure.[3]

Pleural plaques are the most common manifestation of asbestos exposure. They serve as a marker for exposure and are not usually associated with symptoms or functional impairment. In general, plaques can be detected on chest radiograph, 20 years from initial exposure.[4]

Exact pathogenesis of pleural plaques formation is unclear. Most accepted theory is thought that fibers reach the pleura via subpleural lymphatic channels. Later on, it causes local inflammatory reaction and eventually fibrosis.[3] At histologic analysis, pleural plaques consist of relatively acellular bundles of collagen in “basket weave” pattern and may contain asbestos fibers, but asbestos bodies are absent.[4]

The differential diagnosis for pleural plaques should include adipose tissue, rib fracture, companion shadows for ribs, and other pleural masses such as metastases.[2]

Asbestos pleural plaque being a marker of asbestos exposure is used for medical surveillance and worker compensation claims. Asbestosis rarely occurs in the absence of pleural plaques; hence, pleural plaques in a patient with interstitial lung disease may provide a clue in making the diagnosis of asbestosis whenever patient does not give history of known asbestos exposure.[3] Pleural plaques may be an independent risk factor for lung cancer death in asbestos-exposed workers and could be used as an additional criterion in the definition of high-risk populations eligible for CT screening of lung cancer.[5]

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Cugell DW, Kamp DW. Asbestos and the pleura: A review. Chest 2004;125:1103-17.  Back to cited text no. 1
    
2.
Roach HD, Davies GJ, Attanoos R, Crane M, Adams H, Phillips S, et al. Asbestos: When the dust settles an imaging review of asbestos-related disease. Radiographics 2002;22:S167-84.  Back to cited text no. 2
    
3.
Peacock C, Copley SJ, Hansell DM. Asbestos-related benign pleural disease. Clin Radiol 2000;55:422-32.  Back to cited text no. 3
    
4.
Kim KI, Kim CW, Lee MK, Lee KS, Park CK, Choi SJ, et al. Imaging of occupational lung disease. Radiographics 2001;21:1371-91.  Back to cited text no. 4
    
5.
Pairon JC, Andujar P, Rinaldo M, Ameille J, Brochard P, Chamming's S, et al. Asbestos exposure, pleural plaques, and the risk of death from lung cancer. Am J Respir Crit Care Med 2014;190:1413-20.  Back to cited text no. 5
    


    Figures

  [Figure 1], [Figure 2], [Figure 3]



 

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