Home | About us | Editorial Board | Search | Ahead of print | Current Issue | Archives | Instructions | Online submissionContact Us   |  Subscribe   |  Advertise   |  Login  Page layout
Wide layoutNarrow layoutFull screen layout
Lung India Official publication of Indian Chest Society  
  Users Online: 709   Home Print this page  Email this page Small font size Default font size Increase font size


 
  Table of Contents    
RESEARCH LETTER
Year : 2019  |  Volume : 36  |  Issue : 4  |  Page : 367-368  

Popcorn lung – Report of a rare case and its significance in a coffee-growing district of Kerala


Department of Pulmonary Medicine, DM Wayanad Institute of Medical Sciences, Wayanad, Kerala, India

Date of Web Publication28-Jun-2019

Correspondence Address:
Prof. Ravindran Chetambath
Department of Pulmonary Medicine, DM Wayanad Institute of Medical Sciences, Wayanad, Kerala
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/lungindia.lungindia_441_18

Rights and Permissions

How to cite this article:
Chetambath R. Popcorn lung – Report of a rare case and its significance in a coffee-growing district of Kerala. Lung India 2019;36:367-8

How to cite this URL:
Chetambath R. Popcorn lung – Report of a rare case and its significance in a coffee-growing district of Kerala. Lung India [serial online] 2019 [cited 2019 Sep 21];36:367-8. Available from: http://www.lungindia.com/text.asp?2019/36/4/367/261711



Sir,

This is with reference to a case of bronchiolitis obliterans who presented to my outpatient department. A 52-year-old female, agricultural worker, presented with a history of cough and breathlessness for the last 10 years. Breathlessness was progressive with few hospital admissions due to exacerbations. There was no history of childhood asthma or family history of asthma. She is a nonsmoker and is exposed to biomass fuel. She used to work in her own coffee estate doing all sundry works since the age of 18 years along with other family members. The family used to roast coffee beans and grind to make coffee powder at home for their personal use. The patient was diagnosed to have bronchial asthma and is on dust powder inhalation of a combination of budesonide and formoterol. The patient had partial improvement with this treatment.

Because her clinical presentation does not match with either asthma or chronic obstructive pulmonary disease (COPD), she was admitted for a reassessment. Her blood routine, blood sugar, and renal function tests were normal. X-ray chest posteroanterior view showed hyperinflation and reticular opacities distributed mainly in both mid and lower zones [Figure 1]. Her spirometry revealed a normal forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and FEV1/FVC ratio. However, maximal midexpiratory flow (MMEF) or forced expiratory flow (FEF) of 25%–75% showed considerable reduction, suggesting a small airway abnormality. High resolution computed tomography (HRCT) thorax revealed reticular shadows, few nodular shadows, and air trapping. Tree in bud lesions were also seen suggestive of respiratory bronchiolitis [Figure 2]. Confirmation of diagnosis with a lung biopsy was suggested, but the patient did not favor any invasive procedure. The clinical and radiological presentation resembled that of “Popcorn Lung” reported in workers of a microwave popcorn plant in Missouri in 2002.[1] This was caused by a flavoring agent termed diacetyl (2,3-butanedione) which is used to give the popcorn a buttery taste.[2] Later, it was reported that this flavoring agent is extensively used in e-cigarettes, favoring the development of this condition among those who use e-cigarettes. Further, it is proved that this chemical is a natural byproduct in coffee-roasting and coffee-grinding processes.[3],[4] Hence, unacceptable levels of diacetyl in these units may cause popcorn lung. In their report, the Centers for Disease Control and Prevention (CDC) confirmed that occupational exposure to diacetyl and a related compound, 2,3-pentanedione, can cause bronchiolitis obliterans and loss of lung function. The CDC also reported that these potentially harmful chemicals were found at higher-than-expected levels at some coffee-processing facilities.[5] Popcorn lung (bronchiolitis obliterans) often is associated with symptoms of cough and shortness of breath, similar to that seen in patients with COPD and asthma. This pathology is irreversible and progressive, and there is no definite treatment. Diagnosis is often delayed due to nonspecific clinical features and is initially treated as asthma or COPD. Lung tissue biopsy is necessary to confirm the diagnosis of bronchiolitis obliterans.
Figure 1: X-ray chest posteroanterior showing hyperinflation and reticular shadows bilaterally

Click here to view
Figure 2: High-resolution computed tomography thorax (upper and lower lobe cuts) showing air-trapping, reticular, nodular shadows and tree in bud lesions bilaterally

Click here to view


A rare case of bronchiolitis obliterans similar to “popcorn lung” is reported here. The clinical significance is that workers exposed to diacetyl, which is a natural byproduct in coffee processing, develop this disease, and a clinical suspicion among coffee plant workers presenting with symptoms of obstructive airway disease will help in early diagnosis. Wayanad district of Kerala state is a moderately high-altitude farmland with coffee plantations and coffee-processing units. An epidemiological research to detect the level of these chemicals in coffee-processing units and to assess its health hazard among workers may help establish a causative relationship.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Akpinar-Elci M, Travis WD, Lynch DA, Kreiss K. Bronchiolitis Obliterans syndrome in popcorn production plant workers. Eur Respir J 2004;24:298-302.  Back to cited text no. 1
    
2.
Schlecht PC, O'Connor PF. NIOSH Manual of Analytical Methods. 4th ed., 3rd Suppl. Cincinnati: Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health (US); 2003.  Back to cited text no. 2
    
3.
Duling MG, LeBouf RF, Cox-Ganser JM, Kreiss K, Martin SB Jr., Bailey RL. Environmental characterization of a coffee processing workplace with obliterative bronchiolitis in former workers. J Occup Environ Hyg 2016;13:770-81.  Back to cited text no. 3
    
4.
Akiyama M, Murakami K, Ohtani N, Iwatsuki K, Sotoyama K, Wada A, et al. Analysis of volatile compounds released during the grinding of roasted coffee beans using solid-phase microextraction. J Agric Food Chem 2003;51:1961-9.  Back to cited text no. 4
    
5.
LeBouf RF, Martin B Jr., Mugford C, Stanton ML, Bailey RL. Evaluation of Exposures and Respiratory Health at a Coffee Roasting and Packaging Facility. Report No. 2015-0082-3287. U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health; 2017.  Back to cited text no. 5
    


    Figures

  [Figure 1], [Figure 2]



 

Top
  
 
  Search
 
  
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
    References
    Article Figures

 Article Access Statistics
    Viewed178    
    Printed2    
    Emailed0    
    PDF Downloaded81    
    Comments [Add]    

Recommend this journal