Home | About us | Editorial Board | Search | Ahead of print | Current Issue | Archives | Instructions | Online submissionContact Us   |  Subscribe   |  Advertise   |  Login  Page layout
Wide layoutNarrow layoutFull screen layout
Lung India Official publication of Indian Chest Society  
  Users Online: 169   Home Print this page  Email this page Small font size Default font size Increase font size


 
  Table of Contents    
CASE REPORT
Year : 2020  |  Volume : 37  |  Issue : 2  |  Page : 158-160  

Obstructive lung disease secondary to compression of the bronchus by an enlarged pulmonary artery


1 St. George's University School of Medicine, Grenada, West Indies
2 Northwell Health, Department of Pulmonary, Critical Care and Sleep Medicine, New Hyde Park, NY, USA
3 Northwell Health, Department of Pulmonary, Critical Care and Sleep Medicine, New Hyde Park; Heart and Lung Research Unit, The Feinstein Institute for Medical Research, Manhasset, NY, USA

Date of Submission16-Sep-2019
Date of Acceptance30-Sep-2019
Date of Web Publication27-Feb-2020

Correspondence Address:
Dr. Arunabh Talwar
Northwell Health, Department of Pulmonary, Critical Care and Sleep Medicine, 410 Lakeville Road, Suite 107 New Hyde Park, NY 11040
USA
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/lungindia.lungindia_436_19

Rights and Permissions
   Abstract 


In clinical practice, the presence of wheezing generally indicates an airway disease. In rare circumstances, adjacent mediastinal structures may compress the tracheobronchial tree leading to obstructive physiology. Compression of the tracheobronchial region by an enlarged pulmonary artery (PA) is exceedingly rare. We present here a case of pulmonary hypertension, where the enlarged PA resulted in obstructive lung physiology with a relevant review of the literature.

Keywords: Bronchial compression, intrathoracic obstruction, obstructive lung disease, pulmonary artery dilatation, pulmonary hypertension


How to cite this article:
Panthappattu J, Sharma V, Verma S, Talwar A. Obstructive lung disease secondary to compression of the bronchus by an enlarged pulmonary artery. Lung India 2020;37:158-60

How to cite this URL:
Panthappattu J, Sharma V, Verma S, Talwar A. Obstructive lung disease secondary to compression of the bronchus by an enlarged pulmonary artery. Lung India [serial online] 2020 [cited 2020 Apr 3];37:158-60. Available from: http://www.lungindia.com/text.asp?2020/37/2/158/279580




   Introduction Top


Diseases of the airways present with airflow limitation leading to obstructive lung physiology. Rarely, problems outside of the conducting airways can lead to such a phenomenon. Airway compression by enlarged blood vessels is one such cause.[1] We present here a case of dynamic right mainstem bronchus compression caused by the enlargement of the pulmonary artery (PA) in a patient with pulmonary hypertension (PHTN).


   Case Report Top


A nonsmoking 74-year-old male with a history of pulmonary embolism was evaluated for dyspnea on exertion and cough. On examination, he was hemodynamically stable, with a room air saturation of 88%. On examination, he had wheezing in both lower lung posterior hemithoraces but was more pronounced on the right side. Echocardiogram showed pulmonary arterial systolic pressure of 65 mmHg. His 6-min walk test was 317 m. Right heart catheterization showed right atrial pressure of 13 mmHg; mean pulmonary arterial pressure of 44 mmHg; mean pulmonary arterial wedge pressure of 14 mmHg; cardiac output of 2.65 L/min; and pulmonary vascular resistance of 11.32 wood units.

Spirometry showed an obstructive pattern [Table 1]. The flow-volume loop also showed flattening in the expiratory phase [Figure 1]. Computed tomography (CT) angiography showed an enlarged PA measuring 7 cm with compression of the right mainstem bronchus by the right PA [Figure 2]. Therapeutic stenting of the airway was entertained; however, he was deemed a high-risk surgical candidate. Instead, we continued medical management and follow-up.
Table 1: Spirometry measurements

Click here to view
Figure 1: Spirogram demonstrating expiratory flattening of flow-volume curve

Click here to view
Figure 2: Computed tomography scan of the chest demonstrating a slit like compression of the right main stem bronchus from the enlarged right pulmonary artery. Please note that the main pulmonary artery trunk is also enlarged

Click here to view



   Discussion Top


This case outlines a rare cause of dyspnea in a patient with pulmonary arterial hypertension with enlarged PA or its branches causing airflow limitation due to extrinsic compression of the airways.

Enlargement in thoracic vascular structures is a known cause of airway compression, which can be classified as congenital or acquired.[1] Congenital vascular malformations causing extrinsic airway obstruction are common in children.[1] In this population, airway cartilage is more elastic and hence susceptible to compression. Acquired vascular malformations leading to tracheobronchial compression are more common in adults. Severe aortic aneurysm secondary to atherosclerosis is the most common cause of bronchial compression in this clinical setting.[2]

PHTN is associated with PA dilatation.[3] The scenario of enlarged PA associated with congenital heart disease likely leading to tracheobronchial compression has been well documented in children.[4] However, pulmonary arterial hypertension with enlarged PA leading to tracheobronchial compression with symptoms of wheezing in adults is distinctively rare. After a review of the literature, we found seven cases of symptomatic bronchial compression by an enlarged PA (averaging approximately 73.67 mm) [Table 2]. In each of these cases, a patient with PHTN was diagnosed and had dyspnea that was unresponsive to treatment. Further investigation identified an enlarged PA with associated bronchial compression.
Table 2: List of cases of symptomatic bronchial vascular compression by enlarged pulmonary artery

Click here to view


Vascular bronchial compression may be misdiagnosed with asthma because of shared presenting symptoms of dyspnea and cough.[5] Chest X-ray is an initial test in patients with respiratory complaints. However, its usefulness is limited in cases of vascular airway compression as the only abnormality seen on a chest X-ray may be mediastinal widening. Pulmonary function tests are a more accurate diagnostic test. The flow-volume loop in bronchial compression may show a characteristic expiratory flattening, as seen in this case [Figure 1]. During expiration, the pleural pressure becomes positive relative to intra-airway pressure. In the presence of external compression, this difference is amplified and is reflected by end-expiratory loop flattening representing variable intrathoracic obstruction.[2] CT angiography is considered the gold standard for defining the vasculature and the spatial relationship between the vessels and the airways. This modality can be combined with bronchoscopy.[1] After identifying the cause, treatment of the lesion is typically attempted by surgical decompression of the vascular abnormality or airway stenting. Although airway stenting in such cases appears to be an attractive alternative as is that it is less invasive, there is always a risk of wall erosion by the stent hence it has not been much reported in these cases.[1] Surgical interventions to relieve the extrinsic airway compression are of high risk in patients with PHTN.[9]


   Conclusion Top


Wheezing in patients can occur from many causes. In patients with PHTN, the cause of wheezing may be the first indication of compression of the tracheobronchial tree from an enlarged PA.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Kanabuchi K, Noguchi N, Kondo T. Vascular tracheobronchial compression syndrome in adults: A review. Tokai J Exp Clin Med 2011;36:106-11.  Back to cited text no. 1
    
2.
Jaijee SK, Ariff B, Howard L, O'Regan DP, Gin-Sing W, Davies R, et al. Left main bronchus compression due to main pulmonary artery dilatation in pulmonary hypertension: Two case reports. Pulm Circ 2015;5:723-5.  Back to cited text no. 2
    
3.
Badagliacca R, Poscia R, Pezzuto B, Papa S, Nona A, Mancone M, et al. Pulmonary arterial dilatation in pulmonary hypertension: Prevalence and prognostic relevance. Cardiology 2012;121:76-82.  Back to cited text no. 3
    
4.
Bové T, Demanet H, Casimir G, Viart P, Goldstein JP, Deuvaert FE. Tracheobronchial compression of vascular origin. Review of experience in infants and children. J Cardiovasc Surg (Torino) 2001;42:663-6.  Back to cited text no. 4
    
5.
Achouh L, Montani D, Garcia G, Jaïs X, Hamid AM, Mercier O, et al. Pulmonary arterial hypertension masquerading as severe refractory asthma. Eur Respir J 2008;32:513-6.  Back to cited text no. 5
    
6.
Morjaria S, Grinnan D, Voelkel N. Massive dilatation of the pulmonary artery in association with pulmonic stenosis and pulmonary hypertension. Pulm Circ 2012;2:256-7.  Back to cited text no. 6
    
7.
Arimura FE, Santiago RS, Gavilanes F, et al. Idiopathic pulmonary arterial hypertension leading to dynamic bronchial compression and orthopnea: a case report of the use of electrical impedance tomography (eit) as a new investigation tool in pulmonary function test. Am J Resp Crit Care 2015;191:Abstract.  Back to cited text no. 7
    
8.
Nokes B, Jensen EA, Cartin-Ceba R. Unusual cause of severe airflow limitation in a patient with eisenmenger syndrome. Am J Respir Crit Care Med 2019;199:e33-4.  Back to cited text no. 8
    
9.
Ramakrishna G, Sprung J, Ravi BS, Chandrasekaran K, McGoon MD. Impact of pulmonary hypertension on the outcomes of noncardiac surgery: Predictors of perioperative morbidity and mortality. J Am Coll Cardiol 2005;45:1691-9.  Back to cited text no. 9
    


    Figures

  [Figure 1], [Figure 2]
 
 
    Tables

  [Table 1], [Table 2]



 

Top
  
 
  Search
 
  
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
    Abstract
   Introduction
   Case Report
   Discussion
   Conclusion
    References
    Article Figures
    Article Tables

 Article Access Statistics
    Viewed117    
    Printed0    
    Emailed0    
    PDF Downloaded40    
    Comments [Add]    

Recommend this journal