Lung India

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 36  |  Issue : 6  |  Page : 476--482

Hypersensitivity pneumonitis: Clinical manifestations – Prospective data from the interstitial lung disease-India registry


Sheetu Singh1, Bridget F Collins2, Bharat B Sharma3, Jyotsana M Joshi4, Deepak Talwar5, Sandeep Katiyar6, Nishtha Singh7, Lawrence Ho2, Jai K Samaria8, Parthasarthi Bhattacharya9, Sudhir Chaudhari10, Tejraj Singh11, Khushboo Pilania12, Sudhakar Pipavath13, Jitesh Ahuja13, Ravindran Chetambath14, Aloke G Ghoshal15, Nirmal K Jain16, HJ Gayathri Devi17, Surya Kant18, Parvaiz Koul19, Raja Dhar20, Rajesh Swarnakar21, Subodh K Katiyar6, Arpita Jindal22, Daya K Mangal23, Virendra Singh7, Ganesh Raghu2 
1 Department Chest and Tuberculosis, SMS Medical College, Jaipur, Rajasthan, India
2 Department of Medicine, Center for Interstitial Lung Diseases, University of Washington, Seattle, WA 98195, USA
3 Department of Medicine, SMS Medical College, Jaipur, Rajasthan, India
4 Department of Pulmonary Medicine, Topiwala National Medical College and BYL Nair Hospital, Mumbai, Maharashtra, India
5 Department of Pulmonary and Sleep Care Medicine, Metro Multispeciality Hospital, Noida, Uttar Pradesh, India
6 Department of Respiratory Medicine, Chest Care Centre, Kanpur, Uttar Pradesh, India
7 Department of Pulmonary Medicine, Asthma Bhawan, Jaipur, Rajasthan, India
8 Department of Chest Disease, Banaras Hindu University, Varanasi, Uttar Pradesh, India
9 Department of Respiratory Medicine, Institute of Pulmocare and Research, Kolkata, West Bengal, India
10 Department of Tuberculosis and Respiratory Diseases, GSVM Medical College, Kanpur, Uttar Pradesh, India
11 Research Division, Asthma Bhawan, Jaipur, Rajasthan, India
12 Department of Radiodiagnosis, Jankharia Imaging, Mumbai, Maharashtra, India
13 Department of Radiology, Center for Interstitial Lung Diseases, University of Washington, Seattle, WA 98195, USA
14 Department of Pulmonary Medicine, Calicut Medical College, Kozhikode, Kerala, India
15 National Allergy Asthma Bronchitis Institute, Kolkata, West Bengal, India
16 Department of Respiratory Medicine, Jain Chest Care Center, Jaipur, Rajasthan, India
17 Department of Respiratory Medicine, MS Ramaiah Medical College, Bengaluru, Karnataka, India
18 Department of Pulmonary Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India
19 Department of Internal and Pulmonary Medicine, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India
20 Department of Pulmonology and Critical Care, Fortis Hospital, Kolkata, West Bengal, India
21 Department of Pulmonology and Respiratory Medicine, Getwell Hospital and Research Institute, Nagpur, Maharashtra, India
22 Department of Pathology, SMS Medical College, Jaipur, Rajasthan, India
23 IIHMR University, Jaipur, Rajasthan, India

Correspondence Address:
Dr. Sheetu Singh
167 Officers Campus Extension, Sirsi Road, Jaipur - 302 012, Rajasthan
India

Context: Multiple environmental factors are associated with development of hypersensitivity pneumonitis (HP), and diagnostic algorithms for the diagnosis of HP have been proposed in recent perspectives. Aims: We analyzed the data of patients with HP from interstitial lung disease (ILD)-India registry. The analysis was performed to (1) find the prevalence of HP, (2) reclassify HP as per a recently proposed classification criterion to assess the level of diagnostic certainty, and (3) identify the causative agents for HP. Setting and Designs: This was a prospective multicenter study of consecutive, consenting adult patients with new-onset ILD from 27 centers across India (March 2012–April 2015). Materials and Methods: The diagnoses were based on prespecified working clinical criteria and multidisciplinary discussions. To assess strength of diagnosis based on available clinical information, patients with HP were subclassified into definite HP, HP with high level of confidence, and HP with low level of confidence using a recent classification scheme. Results: Five hundred and thirteen of 1084 patients with new-onset ILD were clinically diagnosed with HP and subclassified as HP with high level of confidence (380, 74.1%), HP with low level of confidence (106, 20.7%), and definite HP (27, 5.3%). Exposures among patients with HP were birds (odds ratios [OR]: 3.52, P < 0.001), air-conditioners (OR: 2.23, P < 0.001), molds (OR: 1.79, P < 0.001), rural residence (OR: 1.64, P < 0.05), and air-coolers (OR: 1.45, P < 0.05). Conclusions: About 47.3% of patients with new-onset ILD in India were diagnosed with HP, the majority of whom were diagnosed as HP with a high level of confidence. The most common exposures were birds, cooling devices, and visible molds.


How to cite this article:
Singh S, Collins BF, Sharma BB, Joshi JM, Talwar D, Katiyar S, Singh N, Ho L, Samaria JK, Bhattacharya P, Chaudhari S, Singh T, Pilania K, Pipavath S, Ahuja J, Chetambath R, Ghoshal AG, Jain NK, Gayathri Devi H J, Kant S, Koul P, Dhar R, Swarnakar R, Katiyar SK, Jindal A, Mangal DK, Singh V, Raghu G. Hypersensitivity pneumonitis: Clinical manifestations – Prospective data from the interstitial lung disease-India registry.Lung India 2019;36:476-482


How to cite this URL:
Singh S, Collins BF, Sharma BB, Joshi JM, Talwar D, Katiyar S, Singh N, Ho L, Samaria JK, Bhattacharya P, Chaudhari S, Singh T, Pilania K, Pipavath S, Ahuja J, Chetambath R, Ghoshal AG, Jain NK, Gayathri Devi H J, Kant S, Koul P, Dhar R, Swarnakar R, Katiyar SK, Jindal A, Mangal DK, Singh V, Raghu G. Hypersensitivity pneumonitis: Clinical manifestations – Prospective data from the interstitial lung disease-India registry. Lung India [serial online] 2019 [cited 2019 Dec 10 ];36:476-482
Available from: http://www.lungindia.com/article.asp?issn=0970-2113;year=2019;volume=36;issue=6;spage=476;epage=482;aulast=Singh;type=0