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Characteristics of oxygen affinity (P50) were determined in various cardiopulmonary disorders. An attempt was made to correlate these with PO2, PCO2, HCO3, COHb, HbA2. 2-3 DPG and glutathione measurements. In cardiac disorders P50 was higher when PaO2, pH or cardiac output were low. In pulmonary disorders, P50 was higher with lower PaO2. P50 values did not relate significantly with 2-3 DPG or glutathione levels.