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Lung India Official publication of Indian Chest Society  
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Year : 1985  |  Volume : 3  |  Issue : 4  |  Page : 177-181

FEV1 Changes Following Oral, Inhalational And Intravenous Salbutamol Administration In Patients With Bronchial Asthma



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R. K Sharma


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Serial Forced Expiratory Volume in first second (FEV1) changes were studied in 30 patients of bronchial asthma following oral, inhalational and introvenous salbutamol administration. The maximum improvement following oral administration of drug was observed at four hours, while maximum improvement following inhalational and intravenous administration occurred at 90 minutes. On inter group comparison, inhalational and intravenous routes were found to be superior to oral route upto 90 minutes, but the difference was statistically non-significant at four hours in inhalational group (P>0.1) and significant in intravenous group (P<0.02). On the other hand, on comparison of inhalational and intravenous routes no significant difference was observed at 15, 45, 90 minutes and at four hours. A high incidence of side effects was observed with intravenous administration of salbutamol, the inhalational route was found to be remarkably free from side effects. Oral route stood in between the two. lnhalational route of salbutamol is recommended for long term management of stable bronchial asthma because of its superior bronchodilatation effect with only minor side effects. For the control of nocturnal exacerbation of asthma, an oral dose may be given in addition and intravenous route may well be kept reserved for patients of acute severe asthma.


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