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Rifampin, isoniazid and ethambutol (RHE) were administered on a daily basis to 20 patients of pulmonary tuberculosis with diabetes mellitus. After nine months of therapy 60% of patients had satisfactory response. Extending the therapy to 12 months improved response rate to 90%. Preliminary results suggest that nine months of RHE may not be fully effective for pulmonary tuberculosis associated with diabetes mellitus.