Source of Support: None, Conflict of Interest: None
The results of the tuberculin test vary and the reports are disparate. In the present study BCG vaccinated and unvaccinated normal healthy children and children with Tuberculous meningitis (TBM) (disseminated form) and primary complex disease (PC) (localised form) were evaluated with respect to their Mantoux (Mx) status and leukocyte migration inhibition test to purified protein derivative (PPD). A sizable number of the BCG vaccinated children were negative to the Mx test, but the in vitro responses (leukocyte migration inhibition test) to PPD of these children were normal. The negative skin test responses were thought to be due to the environmental mycobacteria. Almost equal number of children with TBM were positive and negative to the Mx test; though most of the children with PC were positive. The study therefore suggested that tuberculin test alone may not indicate the protective immune status of the child, conferred by BCG.