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Lung India Official publication of Indian Chest Society  
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Year : 1989  |  Volume : 7  |  Issue : 3  |  Page : 130-133

Immunological Studies In Children With Primary Complex And Tuberculous Meningitis

Correspondence Address:
D. V Rao

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Source of Support: None, Conflict of Interest: None

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The immunological parameters in children with Tuberculous meningitis (TBM; n =52) and Primary complex (PC; n =25) were compared, with regard to their BCG status & tuberculin reaction. Comparison was also made with the immune responses of 60 normal children. T and B cells, serum immunoglobulins (IgG,A, M) and leucocyte migration inhibition test (LMIT) with a mitogen and specific antigen were estimated. Although T-and B cells and non-specific invitro CMI responses were normal in both types, specific responses to PPD antigen were negative only in children with PC. Mx-positive (reactive) children with PC had negative mean LMI value and vice-versa. On the contrary Mx-negative (non-reactive) children with TBM had significantly low mitogenic LMI responses, Igs were elevated in all the diseased children. There are differences in the cellular immune responses between children with PC and TBM. BCG seems to be effective in protecting children from PC as well as TBM.

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