Source of Support: None, Conflict of Interest: None
The regimes SHR, SHE (25 mg/Kg) SHE (35 mg/Kg) were administered to three groups of patients with smear positive tuberculosis. The serum copper and zinc levels were estimated at the start, at one month and two months of the chemotherapy. These were compared to 25 controls. Ethambutol toxicity was dose related and not correlated with copper or zinc levels. Malnutrition may be a contributing factor in inducing ocular toxicity.