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Serum zinc and copper levels and erythrocyte sedimentation rates were determined in 25 healthy controls and 50 bacteriologically proven pulmonary tuberculosis patients to assess their response to antitubercular treatment and their relationship with radiographic extent of disease. There was a significant fall In serum zinc (p<0.001) and a significant rise In serum copper (p<0.001) levels In untreated pulmonary tuberculosis patients. The rise in serum copper level was related to the radiologically moderately and far advanced disease; however, serum zinc and ESR did not have any such relationship. The elevated serum copper and ESR had shown a significant fall and the decreased serum zinc had shown a significant rise following antituberculosis treatment.