Source of Support: None, Conflict of Interest: None
Exposure to cotton dust produces acute changes In FEV1 over a shift and chronic changes as evidenced by loss of percentage of predicted value. In this report pre- and post- shift difference in FEF25-75% value and percentage of predicted FEF25-75% in control and exposed workers (non-byssinotics and byssinotics) were evaluated and related to blood histamine levels. The results revealed that the percentage of predicted FEF25-75% showed higher reduction in byssinotics than non-byssinotics and acute changes in FEF25-75% also showed greater decline in byssinotics, than non-byssinotics. This study suggests that FEF25-75% is an early Indicator of airway (small airway) obstruction in byssinotics.