Source of Support: None, Conflict of Interest: None
A total of 1441 patients were admitted to a study containing Short Course regimen with three anti - tuberculosis drugs viz., Rifampicin, Isoniazid and Pyrazinamide over a period of four years in Pondicherry and 986 completed treatment. Fifty-nine (6%) of those who had completed treatment, complained of one or more adverse reactions with the drugs. Jaundice was reported by eight (0.8%), giddiness by 16 (1.6%) joint pains by 17 (1.77%), vomiting by six (0.3%), gastritis by six (0.6%) and skin rashes by three (0.3%). The acceptability of the drug under programe conditions is encouraging. The biochemical investigations carried out in a section of the 1441 patients are also presented and discussed.