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Twenty-four healthy guieapigs were infected with mycobacterium tuberculosis (H37 RV strain) and were divided into sets. A and B. Animals of set A were exposed to Rifampicin mlst (1%) for one minute and that of set B to propylene glycol. Weekly weight was recorded for six weeks or in between if guineapigs died. Loss of weight was more marked in guineapigs of set B. Animals of set A had either no pathological lesion or lesser extent of tuberculosis than that of set B. All the guineapigs set A survived for six weeks whereas it was 50% in set B. Rifampicin aerosol therapy is effective in protecting tuberculous lesions in experimentally induced tuberculosis.