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Lung India Official publication of Indian Chest Society  
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Year : 2000  |  Volume : 18  |  Issue : 2  |  Page : 54-58

Multi Drug Resistance In Human Lung Cancer And Its Pharmacological Reversal



Correspondence Address:
Rakesh C Gupta


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Source of Support: None, Conflict of Interest: None


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Resistance to anti cancer drugs is not so uncommon and often limits the efficacy of given regimen with the consequences of loss of precious time, money and untoward drug reactions. Among the known mechanisms for drug resistance with cytotoxic agents, some are relevant to lung cancer cell lines. These includes reduced drug accumulation as a result of genetic alteration in drug transportation (carrier proteins), enhanced drug inactivation, target enzyme alteration, enhanced DNA repair and apoptosis. Interventions to circumvent resistance are still under evaluation. Use of verapamil to block P-170 glycoprotein, amphotericin-B and dipyridamole to enhance cellular transport of cisplatin, ethacrynic acid to decrease thiotepa inactivation, pentoxyphylline to retard DNA rapair process, ceftriaxone to reduce multidrug resistance and paclitaxel as a biological response modifier are some examples which hold promise for regular clinical utility.


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