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Lung India Official publication of Indian Chest Society  
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Year : 2000  |  Volume : 18  |  Issue : 3  |  Page : 84-88

Scar Cancer Of The Lung : Current Concepts And Literature Review

Correspondence Address:
Rakesh C Gupta

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Source of Support: None, Conflict of Interest: None

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Scar carcinoma arising from old pulmonary scars is an established entity pathologically and is not uncommon in clinical practice. Presumably, it originates in epithelial metaplasia with ultimate carcinoma. Recent evidences suggest that central scars develop within pre-existing tumors rather than the reverse. Studies of collagen type indicates that collagen type III, characteristics of recent fibrogensis, is abundant in the center of 'scar cancers' whereas mature pre-existing lung scars in other situations show little type III collagen but abundant type I and V collagen. Further studies indicates that scar represents a desmoplastic reaction to tumour or arises within the tumour following collapse and/or necrosis. Although there is general belief that most scar cancers are adenocarcinoma, however in Indian studies, squamous cell carcinoma is more common scar cancer, possibly indicating supplement role of smoking. The present review also highlights on the biological behaviour and clinical implications of these tumours.

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