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Lung India Official publication of Indian Chest Society  
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   2000| April-June  | Volume 18 | Issue 2  
    Online since January 5, 2011

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Maximal Mouth Pressure Estimation As A Parameter Of Respiratory Muscle Function In Healthy Medical Students
Z. K Misri, R. C Sahoo
April-June 2000, 18(2):42-46
Maximal mouth pressure may be used to evaluate respiratory muscle strength and follow the progress in patients with neuromuscular disorders, dyspnoea and respiratory failure. For any meaningful interpretation of these values, one needs to know the previous normal values of the person. An alternative method is to compare the values with those predicted for the particular individual based on physical parameters. Two hundred clinically healthy medical students between 18-25 years (100 males and 100 females) without any respiratory, neuromuscular, cardiac and endocrinal disorders were included. Maximal expiratory pressure at total lung capacity and maximal inspiratory pressure at residual volume were measured using Pmax Morgan mouth pressure monitor. Predictive equation have been drawn based on coefficients of chest expansion, weight and body surface area. There was a significant relationship between chest expansion and weight. The inspiratory and expiratory pressures recorded in males and females were lower when compared to Western literature.
[ABSTRACT]   Full text not available  [PDF]
  409 188 -
Ipratropium Bromide In COPD Patients Undergoing FOB - Comfort, Complicance And Complications - Pilot Study
V. K Arora, Sandeep Nayar, U Uma Shankar
April-June 2000, 18(2):50-53
A Pilot study of 10 patients each of COPD in Study group and control group was carried out to find comfort, compliance and complications during bronchoscopy. The results indicate that ipratropium bromide can be considered as another agent for premedication in patients of COPD undergoing bronchocopy.
[ABSTRACT]   Full text not available  [PDF]
  345 142 -
A Placebo Controlled Evaluation Of Intravenous Aminophylline In Acute Asthma
J Whig, Sandeep Puri, R Mahajan, S. C Chopra, Naveen Mittal, Simmi Malhotra
April-June 2000, 18(2):47-49
In a placebo-controlled study; forty patients of acute asthma were randomly allocated to two groups of 20 patients each. The treatment group received aminophylline bolus injection followed by infusion, in addition to intravenous hydrocortisone and nebulised salbutamol. The control group received placebo instead of aminophylline. Rest of the treatment remained the same. Both the groups were followed up for 13 hours during which their clinical response in the form of Wood’s asthma score and objective response by Peak Expiratory Flow Rate (PEFR) were monitored at 0, 1, 5, 9 and 13 hours. Aminophylline levels were estimated at 2 and 8 hours. Wood's asthma score and PEFR showed significant improvement in both the groups as compared to 0 hour (p< 0.001) but the two groups did not differ from each other at any point of time (p > 0.05). The mean serum theophylline concentration in the treatment group was 14.93 ± 4.33 µg/dl at 2 hours and 14.64 ± 4.7 µg/dl at 8 hours, both of which were within the therapeutic range. The adverse drug reactions were more frequent in the treatment group as compared to the control group. Our study showed that theophylline adds to the toxicity and cost of treatment of acute asthma with no additional benefit.
[ABSTRACT]   Full text not available  [PDF]
  384 102 -
Lung Static Pressure - Volume Analysis Can Demonstrate Alveolar Involvement In Pulmonary Alveolar Microlithiasis
Dheeraj Gupta, Ashutosh N Aggarwal, Surinder K Jindal
April-June 2000, 18(2):64-65
A 30 year old housewife presenting with cor pulmonale was diagnosed as having pulmonary alveolar microlithiasis. Exponential analysis of static pressure-volume data obtained through whole body plethysmography revealed decreased compliance, normal shape constant and reduced extrapolated lung volume at infinite distending pressures. These changes were consistent with a restrictive ventilatory defect due to alveolar filling process, and closely correlate with the lung histology seen in this disease.
[ABSTRACT]   Full text not available  [PDF]
  332 93 -
Multi Drug Resistance In Human Lung Cancer And Its Pharmacological Reversal
Rakesh C Gupta, Gurudas Khilnani, Ramakant Dixit
April-June 2000, 18(2):54-58
Resistance to anti cancer drugs is not so uncommon and often limits the efficacy of given regimen with the consequences of loss of precious time, money and untoward drug reactions. Among the known mechanisms for drug resistance with cytotoxic agents, some are relevant to lung cancer cell lines. These includes reduced drug accumulation as a result of genetic alteration in drug transportation (carrier proteins), enhanced drug inactivation, target enzyme alteration, enhanced DNA repair and apoptosis. Interventions to circumvent resistance are still under evaluation. Use of verapamil to block P-170 glycoprotein, amphotericin-B and dipyridamole to enhance cellular transport of cisplatin, ethacrynic acid to decrease thiotepa inactivation, pentoxyphylline to retard DNA rapair process, ceftriaxone to reduce multidrug resistance and paclitaxel as a biological response modifier are some examples which hold promise for regular clinical utility.
[ABSTRACT]   Full text not available  [PDF]
  330 86 -
Cryptogenic Organising Pneumonia Presenting A Bilateral Non - Resolving Pneumonia
M. D Vyas, S Galwankar, Z. F Udwadia, R. B Deshpande
April-June 2000, 18(2):62-63
Full text not available  [PDF]
  236 133 -
Pulse Oximetry - A Useful Tool For Pulmonologist
K. B Gupta, Sushil Dhamija, Sanjiv Tandon
April-June 2000, 18(2):59-61
Full text not available  [PDF]
  148 96 -
Tuberculous Osteomyelitis Of Skull - A Case Report
Ashok Janmeja, Sanjeev Tandon, K. B Gupta, Prem Parkash
April-June 2000, 18(2):66-67
Full text not available  [PDF]
  146 84 -
Polymerase Chain Reaction For Mycobacterium Tuberculosis
K Gowrinath
April-June 2000, 18(2):68-69
Full text not available  [PDF]
  137 84 -